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    ppk3 pickpocket 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246504, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppk3provided by FlyBase
    Official Full Name
    pickpocket 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0050181
    Locus tag
    Dmel_CG30181
    See related
    AllianceGenome:FB:FBgn0050181
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15872; cg30181; CG30181; Dmel\CG30181
    Summary
    Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ppk3 in Genome Data Viewer
    Location:
    59E3-59E3; 2-103 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23538631..23540773, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19426154..19428296, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene RabX1 Neighboring gene minus Neighboring gene brown Neighboring gene Gustatory receptor 59e Neighboring gene Gustatory receptor 59f

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of chromatin structure of genes silenced by heterochromatin in trans. Nisha P, et al. Genetics, 2008 May. PMID 18493059, Free PMC Article
    2. TEMPLE: analysing population genetic variation at transcription factor binding sites. Litovchenko M, et al. Mol Ecol Resour, 2016 Nov. PMID 27106869
    3. ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster. Lu B, et al. PLoS Genet, 2012. PMID 22438833, Free PMC Article
    4. Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC). Ben-Shahar Y. Adv Genet, 2011. PMID 22099690, Free PMC Article
    5. Evolution of the Insect PPK Gene Family. Latorre-Estivalis JM, et al. Genome Biol Evol, 2021 Sep 1. PMID 34390578, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pickpocket 3
    Names
    CG30181-PA
    ppk3-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23538631..23540773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166606.1 → NP_726336.1  pickpocket 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726336.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MLR6
      Related
      FBpp0072025, FBtr0072116
      Conserved Domains (1) summary
      pfam00858
      Location:59 → 464
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MLR6 Q8MLR6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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