sei seizure [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: seiprovided by FlyBase
Official Full Name: seizureprovided by FlyBase
Primary source: FLYBASE:FBgn0003353
Locus tag: Dmel_CG3182
See related: AllianceGenome:FB:FBgn0003353
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3182; Derg; Dmel\CG3182; erg; Sei; seit
Summary: Predicted to enable inward rectifier potassium channel activity. Involved in sensory perception of sound. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adult CNS glial cell; adult brain; adult head; adult ventral nerve cord; and presumptive embryonic/larval central nervous system. Used to study epilepsy and heart conduction disease. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to several human genes including KCNH2 (potassium voltage-gated channel subfamily H member 2) and KCNH7 (potassium voltage-gated channel subfamily H member 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 60B5-60B6; 2-106 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24047411..24053035)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19934934..19940558)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In fruit fly, mutations in the ERG voltage-gated potassium channel seizure (sei), an ortholog of the human hERG channel that has been previously implicated in the cardiac Long-QT syndrome, also increases seizure susceptibility. Study demonstrated that in addition to its cardiac expression, the sei channel is broadly expressed in the nervous system.
Title: The Drosophila ERG channel seizure plays a role in the neuronal homeostatic stress response.
Mutations in sei channels cause arrhythmias that become progressively more severe with age.
Title: Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic cation channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion transport	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated potassium channel complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: seizure

Names: CG3182-PA; CG3182-PB; CG3182-PC; Ether-a-go-go-related; Seizure/HERG; eag related gene; sei-PA; sei-PB; sei-PC; seizure potassium channel

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

24047411..24053035

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299885.1 → NP_001286814.1 seizure, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286814.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JPB9

Conserved Domains (4) summary

COG0664
Location:666 → 766

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:657 → 767

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:360 → 583

Ion_trans; Ion transport protein

pfam07885
Location:526 → 580

Ion_trans_2; Ion channel
NM_166653.2 → NP_726408.1 seizure, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726408.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JPB9

Related

FBpp0072079

Conserved Domains (4) summary

COG0664
Location:666 → 766

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:657 → 767

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:360 → 583

Ion_trans; Ion transport protein

pfam07885
Location:526 → 580

Ion_trans_2; Ion channel
NM_057365.4 → NP_476713.1 seizure, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476713.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JPB9

Related

FBpp0072078

Conserved Domains (4) summary

COG0664
Location:666 → 766

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:657 → 767

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:360 → 583

Ion_trans; Ion transport protein

pfam07885
Location:526 → 580

Ion_trans_2; Ion channel