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    CAH4 Carbonic anhydrase 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42965, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CAH4provided by FlyBase
    Official Full Name
    Carbonic anhydrase 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0039235
    Locus tag
    Dmel_CG10899
    See related
    AllianceGenome:FB:FBgn0039235
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT02719; CG10899; Dmel\CG10899
    Summary
    Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Orthologous to human CA6 (carbonic anhydrase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CAH4 in Genome Data Viewer
    Location:
    96B1-96B1; 3-86 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24856383..24857559, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20682105..20683281, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Nicastrin Neighboring gene Histone deacetylase 11 Neighboring gene pickpocket 22 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Carbonic anhydrases and anion transport in mosquito midgut pH regulation. Linser PJ, et al. J Exp Biol, 2009 Jun. PMID 19448076, Free PMC Article
    2. Sex-specific expression of alternative transcripts in Drosophila. McIntyre LM, et al. Genome Biol, 2006. PMID 16934145, Free PMC Article
    3. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    4. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article
    5. Systematic genetic analysis of muscle morphogenesis and function in Drosophila. Schnorrer F, et al. Nature, 2010 Mar 11. PMID 20220848

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carbonic anhydrase 4
    Names
    CAH4-PA
    CAH4-PC
    CG10899-PA
    CG10899-PC
    NP_001247297.1
    NP_651298.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24856383..24857559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143041.3 → NP_651298.1  carbonic anhydrase 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651298.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMV4, Q8MZG0
      Related
      FBpp0084107
      Conserved Domains (1) summary
      cd00326
      Location:35 → 274
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    2. NM_001260368.1 → NP_001247297.1  carbonic anhydrase 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247297.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV79
      Conserved Domains (1) summary
      cd00326
      Location:21 → 195
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C8VV79 C8VV79
    Q8IMV4 Q8IMV4
    Q8MZG0 Q8MZG0

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