U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GABA-B-R1 metabotropic GABA-B receptor subtype 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34878, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GABA-B-R1provided by FlyBase
    Official Full Name
    metabotropic GABA-B receptor subtype 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0260446
    Locus tag
    Dmel_CG15274
    See related
    AllianceGenome:FB:FBgn0260446
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.175; anon-WO0170980.176; BG:DS00929.6; CG15274; D-GABA-B-R1; D-Gaba1; D-GABA[[B]]R1; dGB1; Dmel\CG15274; GABA; GABA(B)R1; Gaba-b-r1; GABA-BR1; GABA-[[B]]-R1; GABA1; GABAB(R1); GABAB-R1; GABA[[B]]; GABA[[B]]-R; GABA[[B]]-R1; GABA[[B]]R; GABA[[B]]R1; GB1
    Old locus tag
    CG15274
    Summary
    Enables G protein-coupled GABA receptor activity and protein heterodimerization activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and gamma-aminobutyric acid signaling pathway. Located in plasma membrane. Part of G protein-coupled receptor heterodimeric complex. Is expressed in adult head; larval brain; larval central nervous system; larval gnathal ganglion; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in alcohol dependence; amphetamine abuse; cocaine dependence; heroin dependence; and nicotine dependence. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GABA-B-R1 in Genome Data Viewer
    Location:
    35B8-35B8; 2-50 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15016331..15034704)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15016331..15034704)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43856 Neighboring gene RNA guanine-7 methyltransferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene yellow-c Neighboring gene Cytokine induced apoptosis inhibitor 1 Neighboring gene Suppressor of Hairless

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Developmental role of GABAB(1) receptors in Drosophila. Dzitoyeva S, et al. Brain Res Dev Brain Res, 2005 Aug 8. PMID 16054235
    2. Cross-modal modulation gates nociceptive inputs in Drosophila. Pan G, et al. Curr Biol, 2023 Apr 10. PMID 36893758, Free PMC Article
    3. Structural basis for distinct quality control mechanisms of GABA(B) receptor during evolution. Zhang S, et al. FASEB J, 2020 Dec. PMID 33058267
    4. Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence. Dzitoyeva S, et al. Proc Natl Acad Sci U S A, 2003 Apr 29. PMID 12692303, Free PMC Article
    5. Fermented Gamma Aminobutyric Acid Improves Sleep Behaviors in Fruit Flies and Rodent Models. Jeong AH, et al. Int J Mol Sci, 2021 Mar 29. PMID 33805468, Free PMC Article

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled GABA receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled GABA receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled GABA receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled GABA receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of G protein-coupled receptor heterodimeric complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of G protein-coupled receptor heterodimeric complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    metabotropic GABA-B receptor subtype 1
    Names
    CG15274-PB
    CG15274-PC
    GABA-B-R1-PB
    GABA-B-R1-PC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15016331..15034704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259104.2 → NP_001246033.1  metabotropic GABA-B receptor subtype 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246033.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WHF3, Q9BML7, Q9V3Q9
      Conserved Domains (3) summary
      cd06366
      Location:34 → 437
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam00003
      Location:476 → 730
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:52 → 415
      ANF_receptor; Receptor family ligand binding region

    2. NM_078845.5 → NP_523569.3  metabotropic GABA-B receptor subtype 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523569.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WHF3, Q9BML7, Q9V3Q9
      Conserved Domains (3) summary
      cd06366
      Location:34 → 437
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam00003
      Location:476 → 730
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:52 → 415
      ANF_receptor; Receptor family ligand binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BML7 Q9BML7
    Q9V3Q9 Q9V3Q9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous