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    fw furrowed [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32162, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fwprovided by FlyBase
    Official Full Name
    furrowedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001083
    Locus tag
    Dmel_CG1500
    See related
    AllianceGenome:FB:FBgn0001083
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1500; CT3745; Dmel\CG1500; Fw; fw-like; wr
    Summary
    Predicted to enable carbohydrate binding activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; imaginal disc-derived wing hair organization; and protein stabilization. Located in apical junction complex. Is expressed in adult head; embryonic/larval proventriculus; eye; and larval brain. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to several human genes including SVEP1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    11A1-11A1; 1-38 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11992915..12003914, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11886948..11897947, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene twisted gastrulation Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene regucalcin Neighboring gene Chromatin accessibility complex 16kD protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of selectins in Drosophila eye and bristle development. Leshko-Lindsay LA, et al. Development, 1997 Jan. PMID 9006078
    2. Single amino acid mutations in Drosophila fascin disrupt actin bundling function in vivo. Cant K, et al. Genetics, 1996 May. PMID 8722779, Free PMC Article
    3. Genetic instability in Drosophila melanogaster: Mutable miniature (mu). Green MM. Mutat Res, 1975 Jul. PMID 807842
    4. The Drosophila selectin furrowed mediates intercellular planar cell polarity interactions via frizzled stabilization. Chin ML, et al. Dev Cell, 2013 Sep 16. PMID 23973164, Free PMC Article
    5. Drosophila suzukii: the genetic footprint of a recent, worldwide invasion. Adrion JR, et al. Mol Biol Evol, 2014 Dec. PMID 25158796, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbohydrate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in establishment of ommatidial planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing hair organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical junction complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    furrowed
    Names
    CG1500-PA
    CG1500-PB
    CG1500-PC
    fw-PA
    fw-PB
    fw-PC
    wrinkled

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11992915..12003914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078581.3 → NP_511136.2  furrowed, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511136.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYR4
      Related
      FBpp0073424
      Conserved Domains (5) summary
      smart00607
      Location:113 → 261
      FTP; eel-Fucolectin Tachylectin-4 Pentaxrin-1 Domain
      cd00033
      Location:525 → 579
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd00037
      Location:281 → 403
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      PHA02927
      Location:637 → 897
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:841 → 896
      Sushi; Sushi repeat (SCR repeat)

    2. NM_001298217.1 → NP_001285146.1  furrowed, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285146.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYR4
      Conserved Domains (5) summary
      smart00607
      Location:113 → 261
      FTP; eel-Fucolectin Tachylectin-4 Pentaxrin-1 Domain
      cd00033
      Location:525 → 579
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd00037
      Location:281 → 403
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
      PHA02927
      Location:637 → 897
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:841 → 896
      Sushi; Sushi repeat (SCR repeat)

    3. NM_001103491.1 → NP_001096961.1  furrowed, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096961.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JUT1
      Conserved Domains (3) summary
      cd00033
      Location:106 → 160
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:218 → 478
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:422 → 477
      Sushi; Sushi repeat (SCR repeat)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JUT1 A8JUT1
    P91658 P91658
    Q9VYR4 Q9VYR4

    Gene LinkOut

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