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    Lcp4 Larval cuticle protein 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35820, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lcp4provided by FlyBase
    Official Full Name
    Larval cuticle protein 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0002535
    Locus tag
    Dmel_CG2044
    See related
    AllianceGenome:FB:FBgn0002535
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4; CG2044; DmelLcp4; Dmel\CG2044; IV; LCP-4; lcp4; LCP4; L[[3]]CP4
    Summary
    A structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Located in chitin-based extracellular matrix. Is expressed in integumentary system and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lcp4 in Genome Data Viewer
    Location:
    44D1-44D1; 2-59 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8437647..8438495)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4325152..4326000)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Larval cuticle protein 2 Neighboring gene Larval cuticle protein 3 Neighboring gene Cytochrome P450 4ad1 Neighboring gene Cytochrome P450 4e2 Neighboring gene mir-986 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of sex chromosomes: dosage compensation of the Lcp1-4 gene cluster on the evolving neo-X chromosome in Drosophila miranda. Steinemann S, et al. Insect Mol Biol, 2007 Apr. PMID 17352708
    2. Chromatin structure at the 44D larval cuticle gene locus in Drosophila: the effect of a transposable element insertion. Eissenberg JC, et al. Nucleic Acids Res, 1984 Dec 11. PMID 6096816, Free PMC Article
    3. The cuticle genes of drosophila: a developmentally regulated gene cluster. Snyder M, et al. Cell, 1981 Jul. PMID 6168386
    4. Evolution of the larval cuticle proteins coded by the secondary sex chromosome pair: X2 and neo-Y of Drosophila miranda: II. Comparison at the amino acid sequence level. Steinemann M, et al. J Mol Evol, 1996 Oct. PMID 8798346
    5. Evolution of the larval cuticle proteins coded by the secondary sex chromosome pair: X2 and neo-Y of Drosophila miranda: I. Comparison at the DNA sequence level. Steinemann M, et al. J Mol Evol, 1996 Oct. PMID 8798345

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chitin-based larval cuticle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of chitin-based larval cuticle ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chitin-based extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chitin-based extracellular matrix ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    larval cuticle protein 4
    Names
    CG2044-PA
    CG2044-PB
    Lcp4-PA
    Lcp4-PB
    cuticle p. IV
    gene IV

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8437647..8438495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057274.4 → NP_476622.1  larval cuticle protein 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476622.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D0IQD9, P07189, Q9V4T2
      UniProtKB/TrEMBL
      A0A0B4KEM6
      Related
      FBpp0087823
      Conserved Domains (1) summary
      pfam00379
      Location:40 → 81
      Chitin_bind_4; Insect cuticle protein

    2. NM_001273875.1 → NP_001260804.1  larval cuticle protein 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260804.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D0IQD9, P07189, Q9V4T2
      UniProtKB/TrEMBL
      A0A0B4KEM6
      Conserved Domains (1) summary
      pfam00379
      Location:40 → 81
      Chitin_bind_4; Insect cuticle protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEM6 A0A0B4KEM6
    P07189.2 P07189

    Gene LinkOut

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