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    Rgk3 Rad, Gem/Kir family member 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740446, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rgk3provided by FlyBase
    Official Full Name
    Rad, Gem/Kir family member 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0085426
    Locus tag
    Dmel_CG34397
    See related
    AllianceGenome:FB:FBgn0085426
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15660; CG15663; CG15664; CG33949; CG34397; Dmel\CG34397; mdcds_15673; mdcds_15683; RGK3
    Old locus tag
    CG15660; CG33949; Dmel_CG15660; Dmel_CG33949
    Summary
    Enables calcium channel regulator activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be active in plasma membrane. Is expressed in adult head and larval brain. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human REM1 (RRAD and GEM like GTPase 1); REM2 (RRAD and GEM like GTPase 2); and RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rgk3 in Genome Data Viewer
    Location:
    57D4-57D6; 2-94 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21255165..21280995)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17142670..17168500)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene UDP-glycosyltransferase family 49 member C1 Neighboring gene Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Major Facilitator Superfamily Transporter 16 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ancient origins of RGK protein function: modulation of voltage-gated calcium channels preceded the protostome and deuterostome split. Puhl HL 3rd, et al. PLoS One, 2014. PMID 24992013, Free PMC Article
    2. Evolutionary expansion of the Ras switch regulatory module in eukaryotes. Díez D, et al. Nucleic Acids Res, 2011 Jul. PMID 21447561, Free PMC Article
    3. Variation in the response to exercise stimulation in Drosophila: marathon runner versus sprinter genotypes. Riddle NC. J Exp Biol, 2020 Sep 21. PMID 32737212
    4. A genetic toolkit for tagging intronic MiMIC containing genes. Nagarkar-Jaiswal S, et al. Elife, 2015 Jun 23. PMID 26102525, Free PMC Article
    5. The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster. Zhou S, et al. Environ Health Perspect, 2016 Jul. PMID 26859824, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables calcium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in small GTPase-mediated signal transduction ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rad, Gem/Kir family member 3
    Names
    CG34397-PC
    CG34397-PE
    CG34397-PF
    CG34397-PG
    Rgk3-PC
    Rgk3-PE
    Rgk3-PF
    Rgk3-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21255165..21280995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032275.2 → NP_001027446.2  Rad, Gem/Kir family member 3, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027446.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYK6, D0IQG6
      Conserved Domains (1) summary
      cl38936
      Location:235 → 449
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001103926.4 → NP_001097396.3  Rad, Gem/Kir family member 3, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYK6, D0IQG6
      Conserved Domains (1) summary
      cl38936
      Location:235 → 449
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001299741.1 → NP_001286670.1  Rad, Gem/Kir family member 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286670.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A076NAB7
      Conserved Domains (1) summary
      cl38936
      Location:235 → 396
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. NM_001103925.3 → NP_001097395.1  Rad, Gem/Kir family member 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097395.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYK6, D0IQG6
      Conserved Domains (1) summary
      cl38936
      Location:235 → 449
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A076NAB7 A0A076NAB7
    A8DYK6 A8DYK6

    Gene LinkOut

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