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    sws swiss cheese [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31716, updated on 9-Dec-2024

    Summary

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    Official Symbol
    swsprovided by FlyBase
    Official Full Name
    swiss cheeseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003656
    Locus tag
    Dmel_CG2212
    See related
    AllianceGenome:FB:FBgn0003656
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2212; Dmel\CG2212; olfE; PNPLA6; Sws; SWS
    Summary
    Enables lysophospholipase activity and protein kinase A catalytic subunit binding activity. Involved in several processes, including glial cell apoptotic process; photoreceptor cell maintenance; and sensory perception of smell. Located in endoplasmic reticulum membrane and plasma membrane. Is expressed in CNS glial cell; adult brain; adult head; and cell body rind of adult lamina. Used to study blindness; cerebellar ataxia; hereditary spastic paraplegia; and neurodegenerative disease. Human ortholog(s) of this gene implicated in Boucher-Neuhauser syndrome; Laurence-Moon syndrome; Oliver-McFarlane syndrome; and hereditary spastic paraplegia 39. Orthologous to several human genes including PNPLA6 (patatin like phospholipase domain containing 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sws in Genome Data Viewer
    Location:
    7D1-7D1; 1-22 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7956820..7968236, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7850853..7862269, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ubr3 ubiquitin ligase Neighboring gene antisense RNA:CR45620 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene singed Neighboring gene Tyramine beta hydroxylase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of an olfactory gene from Drosophila melanogaster. Hasan G. Proc Natl Acad Sci U S A, 1990 Nov. PMID 2123349, Free PMC Article
    2. The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila. Kretzschmar D, et al. J Neurosci, 1997 Oct 1. PMID 9295388, Free PMC Article
    3. Membrane association of and critical residues in the catalytic domain of human neuropathy target esterase. Atkins J, et al. J Biol Chem, 2000 Aug 11. PMID 10816586
    4. Drosophila Lysophospholipase Gene swiss cheese Is Required for Survival and Reproduction. Melentev PA, et al. Insects, 2021 Dec 22. PMID 35055857, Free PMC Article
    5. Characterization of lysophosphatidylcholine-induced changes of intracellular calcium in Drosophila S2 cells. Wang P, et al. Life Sci, 2015 Jun 15. PMID 25736969

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of swiss cheese in Neurons Contributes to Neurodegeneration with Mitochondria Abnormalities, Reactive Oxygen Species Acceleration and Accumulation of Lipid Droplets in Drosophila Brain.
      Title: Loss of swiss cheese in Neurons Contributes to Neurodegeneration with Mitochondria Abnormalities, Reactive Oxygen Species Acceleration and Accumulation of Lipid Droplets in Drosophila Brain.
    2. sws flies showed an activated ER stress response as determined by elevated levels of the chaperone GRP78 and by increased splicing of XBP, an ER transcription factor that activates transcriptional ER stress responses.
      Title: ER responses play a key role in Swiss-Cheese/Neuropathy Target Esterase-associated neurodegeneration.
    3. the loss of SWS in glia impairs neuronal function.
      Title: Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and function.
    4. inducible, neuron-specific expression of full-length human wildtype NTE reduces vacuole formation and substantially rescues mobility.
      Title: Delayed Induction of Human NTE (PNPLA6) Rescues Neurodegeneration and Mobility Defects of Drosophila swiss cheese (sws) Mutants.
    5. OP-modified SWS cannot release PKA-C3 and the resulting loss of PKA-C3 activity plays a crucial role in developing the delayed symptoms of organophosphate-induced delayed neuropathy but not in the acute toxicity
      Title: Organophosphate-induced changes in the PKA regulatory function of Swiss Cheese/NTE lead to behavioral deficits and neurodegeneration.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lysophospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophospholipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysophospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase A catalytic subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ensheathment of neurons IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in membrane organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylcholine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylcholine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photoreceptor cell maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    swiss cheese
    Names
    CG2212-PA
    CG2212-PB
    CG2212-PC
    olfactory E
    olfactory-E
    swiss-cheese
    swisscheese
    sws-PA
    sws-PB
    sws-PC
    NP_511075.3
    NP_727224.2
    NP_727225.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7956820..7968236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167140.2 → NP_727224.2  swiss cheese, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727224.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJF4
      Conserved Domains (4) summary
      cd07225
      Location:935 → 1240
      Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
      COG0664
      Location:168 → 310
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      COG1752
      Location:940 → 1222
      RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]
      cd00038
      Location:620 → 719
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    2. NM_078520.3 → NP_511075.3  swiss cheese, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511075.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8E6M7, Q8IRN7, Q95RE9, Q9U969, Q9W3M0
      Related
      FBpp0071077
      Conserved Domains (4) summary
      cd07225
      Location:935 → 1240
      Pat_PNPLA6_PNPLA7; Patatin-like phospholipase domain containing protein 6 and protein 7
      COG0664
      Location:168 → 310
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      COG1752
      Location:940 → 1222
      RssA; Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only]
      cd00038
      Location:620 → 719
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    3. NM_167141.3 → NP_727225.1  swiss cheese, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727225.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U969
      Related
      FBpp0071078
      Conserved Domains (1) summary
      cl11396
      Location:1 → 156
      Patatin_and_cPLA2; Patatins and Phospholipases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JJF4 E1JJF4
    Q9U969.2 Q9U969

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