Sik2 Salt-inducible kinase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sik2provided by FlyBase
Official Full Name: Salt-inducible kinase 2provided by FlyBase
Primary source: FLYBASE:FBgn0025625
Locus tag: Dmel_CG4290
See related: AllianceGenome:FB:FBgn0025625
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4290; Dmel\CG4290; EG:22E5.8; SIK; sik2; SIK2
Summary: Enables protein serine/threonine kinase activity. Involved in insulin receptor signaling pathway; negative regulation of hippo signaling; and response to starvation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult Dh44 neuron of pars intercerebralis; adult ventral nerve cord; anterior-posterior subdivision of organism; brain; and embryonic/larval fat body. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 30. Orthologous to several human genes including SIK2 (salt inducible kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (2055310..2061915, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (1949343..1955948, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drosophila salt-inducible kinases Sik2 and Sik3 are negative regulators of Hpo signalling.
Title: Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

NP_569972.1

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The following sections contain reference sequences that belong to a specific genome build. Explain