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    mino minotaur [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43350, updated on 9-Dec-2024

    Summary

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    Official Symbol
    minoprovided by FlyBase
    Official Full Name
    minotaurprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027579
    Locus tag
    Dmel_CG5508
    See related
    AllianceGenome:FB:FBgn0027579
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    152088_at; BcDNA:GH07066; CG5508; Dmel\CG5508; DmGPAT1/2; GPAT1; Mino; MINO
    Summary
    Predicted to enable glycerol-3-phosphate O-acyltransferase activity. Involved in primary piRNA processing. Located in several cellular components, including female germline ring canal; fusome; and mitochondrial outer membrane. Is expressed in adult head and organism. Orthologous to several human genes including GPAM (glycerol-3-phosphate acyltransferase, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mino in Genome Data Viewer
    Location:
    98B6-98B6; 3-94 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27925191..27933077)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23750913..23758799)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene BCAS2 Neighboring gene long non-coding RNA:CR45566 Neighboring gene Ribosomal protein L4 Neighboring gene antisense RNA:CR46452 Neighboring gene nenya Neighboring gene Nuclear receptor binding SET domain protein Neighboring gene Biorientation Defective 1 Neighboring gene mitoferrin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A pathogenic variant in the uncharacterized RNF212B gene results in severe aneuploidy male infertility and repeated IVF failure. Gershoni M, et al. HGG Adv, 2023 Jul 13. PMID 37124137, Free PMC Article
    2. SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase. Pagac M, et al. Cell Rep, 2016 Nov 1. PMID 27806294, Free PMC Article
    3. Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation. Tian Y, et al. PLoS Genet, 2011 Apr. PMID 21533227, Free PMC Article
    4. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Wilfling F, et al. Dev Cell, 2013 Feb 25. PMID 23415954, Free PMC Article
    5. Silencing of Transposable Elements by piRNAs in Drosophila: An Evolutionary Perspective. Luo S, et al. Genomics Proteomics Bioinformatics, 2017 Jun. PMID 28602845, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerophospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerophospholipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in primary piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in female germline ring canal IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fusome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    minotaur
    Names
    CG5508-PA
    CG5508-PB
    CG5508-PC
    CG5508-PE
    mino-PA
    mino-PB
    mino-PC
    mino-PE
    NP_001247343.2
    NP_651597.1
    NP_733237.1
    NP_733238.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27925191..27933077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143340.4 → NP_651597.1  minotaur, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651597.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPB4, Q9Y137
      Related
      FBpp0084618
      Conserved Domains (2) summary
      cd07993
      Location:232 → 443
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
      COG2937
      Location:52 → 650
      PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

    2. NM_001260414.2 → NP_001247343.2  minotaur, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247343.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPB4, Q9Y137
      Conserved Domains (2) summary
      cd07993
      Location:232 → 443
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
      COG2937
      Location:52 → 650
      PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

    3. NM_170358.2 → NP_733237.1  minotaur, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733237.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPB4, Q8IMM8
      Related
      FBpp0084619
      Conserved Domains (2) summary
      cd07993
      Location:168 → 379
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
      COG2937
      Location:61 → 586
      PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]

    4. NM_170359.3 → NP_733238.1  minotaur, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733238.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPB4, Q8IMM7
      Related
      FBpp0084620
      Conserved Domains (2) summary
      cd07993
      Location:139 → 350
      LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
      COG2937
      Location:32 → 557
      PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IMM7 Q8IMM7
    Q8IMM8 Q8IMM8
    Q9Y137 Q9Y137

    Gene LinkOut

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