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    rtet tetracycline resistance [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42500, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rtetprovided by FlyBase
    Official Full Name
    tetracycline resistanceprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028468
    Locus tag
    Dmel_CG5760
    See related
    AllianceGenome:FB:FBgn0028468
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0119857.1; BcDNA:LD28419; CG5760; Dmel\CG5760; Drtet; l(3)07086
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in brush border membrane. Is expressed in embryonic anal pad; embryonic foregut; embryonic head epidermis; embryonic hindgut; and organism. Orthologous to human MFSD10 (major facilitator superfamily domain containing 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rtet in Genome Data Viewer
    Location:
    93B12-93B12; 3-70 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21108446..21110834)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16934168..16936556)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46045 Neighboring gene TBC1 domain family member 22 Neighboring gene Secretory 15 Neighboring gene Rab11 Neighboring gene peter pan Neighboring gene Bride of doubletime

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary. Bogard N, et al. Development, 2007 Oct. PMID 17715175
    2. Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components. Mehta SQ, et al. Neuron, 2005 Apr 21. PMID 15848801
    3. Glucose Availability Alters Gene and Protein Expression of Several Newly Classified and Putative Solute Carriers in Mice Cortex Cell Culture and D. melanogaster. Ceder MM, et al. Front Cell Dev Biol, 2020. PMID 32733888, Free PMC Article
    4. Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. Perland E, et al. Open Biol, 2017 Sep. PMID 28878041, Free PMC Article
    5. Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations. Perrimon N, et al. Genetics, 1996 Dec. PMID 8978055, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in brush border membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetracycline resistance
    Names
    CG5760-PA
    rtet-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21108446..21110834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079705.3 → NP_524429.1  tetracycline resistance [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524429.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V395
      Related
      FBpp0083412
      Conserved Domains (2) summary
      cd06174
      Location:105 → 466
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:108 → 442
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V395 Q9V395

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