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    dre4 dre4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38248, updated on 17-Dec-2024

    Summary

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    Official Symbol
    dre4provided by FlyBase
    Official Full Name
    dre4provided by FlyBase
    Primary source
    FLYBASE:FBgn0002183
    Locus tag
    Dmel_CG1828
    See related
    AllianceGenome:FB:FBgn0002183
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1828; Dmel\CG1828; Dre4; DRE4; DRE4/dSPT16; dspt16; dSpt16; dSPT16; l(3)62Bg; l(3)dre4; spt16; Spt16; SPT16
    Summary
    Enables nucleosome binding activity and protein heterodimerization activity. Involved in positive regulation of transcription elongation by RNA polymerase II and regulation of chromatin organization. Located in cytosol; nucleolus; and polytene chromosome puff. Part of FACT complex. Colocalizes with polytene chromosome interband. Is expressed in adult head and spermatozoon. Used to study neurodevelopmental disorder with dysmorphic facies and thin corpus callosum. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with dysmorphic facies and thin corpus callosum. Orthologous to human SUPT16H (SPT16 homolog, facilitates chromatin remodeling subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dre4 in Genome Data Viewer
    Location:
    62B7-62B7; 3-1.0 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1871574..1876312, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1871574..1876312, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Adenine phosphoribosyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription elongation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of FACT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of FACT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of FACT complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with polytene chromosome interband IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with polytene chromosome puff IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome puff IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dre4
    Names
    CG1828-PA
    CG1828-PB
    dre4-PA
    dre4-PB
    lethal(3)62Bg
    supressor of Ty element 16

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1871574..1876312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167922.3 → NP_728686.2  dre4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728686.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17045, O17046, Q7YTY1, Q86SB9, Q8IRG6, Q9W071
      Related
      FBpp0072744
      Conserved Domains (5) summary
      COG5406
      Location:1 → 1005
      COG5406; Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and repair, Chromatin structure and dynamics]
      cd01091
      Location:181 → 421
      CDC68-like; Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in cell division control protein 68, a transcription factor.
      pfam08512
      Location:819 → 895
      Rtt106; Histone chaperone Rttp106-like
      pfam08644
      Location:540 → 695
      SPT16; FACT complex subunit (SPT16/CDC68)
      pfam14826
      Location:6 → 166
      FACT-Spt16_Nlob; FACT complex subunit SPT16 N-terminal lobe domain

    2. NM_057262.4 → NP_476610.2  dre4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476610.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IRG6
      Related
      FBpp0072743
      Conserved Domains (5) summary
      COG5406
      Location:1 → 1005
      COG5406; Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and repair, Chromatin structure and dynamics]
      cd01091
      Location:181 → 421
      CDC68-like; Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in cell division control protein 68, a transcription factor.
      pfam08512
      Location:819 → 895
      Rtt106; Histone chaperone Rttp106-like
      pfam08644
      Location:540 → 695
      SPT16; FACT complex subunit (SPT16/CDC68)
      pfam14826
      Location:6 → 166
      FACT-Spt16_Nlob; FACT complex subunit SPT16 N-terminal lobe domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IRG6.2 Q8IRG6

    Gene LinkOut

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