lic licorne [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: licprovided by FlyBase
Official Full Name: licorneprovided by FlyBase
Primary source: FLYBASE:FBgn0261524
Locus tag: Dmel_CG12244
See related: AllianceGenome:FB:FBgn0261524
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12244; D-MKK3; DMEK3; Dmel\CG12244; dMKK3; DMKK3; DMKK3/lic; DmMKK3; l(1)G0252; Licorne; Mek3; MEK3; MEK3/MKK3; Mkk3; MKK3; Mpk3; p38; p38MAPKK
Summary: Enables MAP kinase kinase activity and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including MAPK cascade; cell surface receptor signaling pathway; and negative regulation of signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including adult head; female germline cell; and gut section. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K3 (mitogen-activated protein kinase kinase 3) and MAP2K6 (mitogen-activated protein kinase kinase 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 11D10-11D10; 1-41 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13091145..13093986)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (12985178..12988019)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lic is able to activate JNK signaling by phosphorylating JNK, which up-regulates the matrix metalloproteinase MMP1 and integrin, characteristics of epithelial-mesenchymal transition.
Title: MKK3 modulates JNK-dependent cell migration and invasion.
Two upstream kinases, apoptotic signal-regulating kinase 1 (Ask1) and Licorne MAP kinase kinase 3 (MKK3), are required for p38 MAP kinase (p38) activation following infection, oxidative stress, detergent exposure and wounding.
Title: Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut.
Loss of lic suppressed ectopic Egr-triggered JNK activation and cell death in eye and wing development. Lic is necessary for loss-of-cell polarity-induced, physiological JNK-dependent cell death in wing development.
Title: Lic regulates JNK-mediated cell death in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase kinase activity	TAS Traceable Author Statement more info	PubMed
enables mitogen-activated protein kinase kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mucosal immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte anterior/posterior axis specification	NAS Non-traceable Author Statement more info	PubMed
involved_in oocyte axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in p38MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of adult chitin-containing cuticle pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wound healing, spreading of epidermal cells	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: licorne

Names: CG12244-PA; MAP kinase kinase 3; MEK-kinase 3; Mkk3; drosophila MAP kinase kinase 3; lic-PA; p38 MAPK

NP_477162.1

EC 2.7.12.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

13091145..13093986

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057814.4 → NP_477162.1 licorne [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477162.1

Status: REVIEWED

UniProtKB/TrEMBL

O62602, Q9U983

Related

FBpp0073551

Conserved Domains (1) summary

cd06617
Location:44 → 326

PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6