Rdh1 Retinol dehydrogenase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rdh1provided by FlyBase
Official Full Name: Retinol dehydrogenase 1provided by FlyBase
Primary source: FLYBASE:FBgn0033205
Locus tag: Dmel_CG2064
See related: AllianceGenome:FB:FBgn0033205
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:SD07613; CG2064; Dmel\CG2064; RDH
Summary: Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in lipid droplet formation; protein localization to lipid droplet; and retinal metabolic process. Located in endoplasmic reticulum membrane. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 13 and Leber hereditary optic neuropathy. Orthologous to several human genes including RDH13 (retinol dehydrogenase 13). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7665828..7667343)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3553333..3554848)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables all-trans-retinol dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables all-trans-retinol dehydrogenase (NADP+) activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in lipid droplet formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to lipid droplet	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endomembrane system	HDA more info	PubMed
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed

NP_610310.2

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The following sections contain reference sequences that belong to a specific genome build. Explain