Aldh Aldehyde dehydrogenase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Aldhprovided by FlyBase
Official Full Name: Aldehyde dehydrogenaseprovided by FlyBase
Primary source: FLYBASE:FBgn0012036
Locus tag: Dmel_CG3752
See related: AllianceGenome:FB:FBgn0012036
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 146084_at; ACDH; ALDH; ALDHA1; CG 3752; CG3752; DmALDH; Dmel\CG3752; FBgn0012036; Q9VLC5; TMABADH
Summary: Enables acetaldehyde dehydrogenase (acetylating) activity and aldehyde dehydrogenase (NAD+) activity. Involved in acetaldehyde metabolic process and response to ethanol. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; anterior endoderm; endoderm anlage; and gut section. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to several human genes including ALDH2 (aldehyde dehydrogenase 2 family member). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 30B1-30B1; 2-35 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (9387389..9391567)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (9387389..9391567)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila lacking a homologue of mammalian ALDH2 have multiple fitness defects.
Title: Drosophila lacking a homologue of mammalian ALDH2 have multiple fitness defects.
An amino acid replacement polymorphism in Aldh that shows hallmarks of contributing to clinally varying traits in D. melanogaster was studied.
Title: A worldwide polymorphism in aldehyde dehydrogenase in Drosophila melanogaster: evidence for selection mediated by dietary ethanol.
Aldh null larvae and adults are poisoned by ethanol concentrations easily tolerated by wild-types; their ethanol sensitivity is comparable to that of Adh nulls suggesting that Aldh and Adh may be equally important in the evolution of ethanol resistance.
Title: Aldehyde dehydrogenase is essential for both adult and larval ethanol resistance in Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables acetaldehyde dehydrogenase (acetylating) activity	IDA Inferred from Direct Assay more info
enables acetaldehyde dehydrogenase (acetylating) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables aldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldehyde dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetaldehyde metabolic process	IMP Inferred from Mutant Phenotype more info
involved_in response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aldehyde dehydrogenase

Names: Aldh-PA; Aldh-PB; CG3752-PA; CG3752-PB; acetaldehyde dehydrogenase; gamma-TriMethylAminoButyrAldehyde DeHydrogenase

NP_001260290.1

EC 1.-.-.-

EC 1.2.1.-

EC 1.2.1.10

EC 1.2.1.3

NP_609285.1

EC 1.-.-.-

EC 1.2.1.-

EC 1.2.1.10

EC 1.2.1.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

9387389..9391567

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_135441.2 → NP_609285.1 aldehyde dehydrogenase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609285.1

Status: REVIEWED

UniProtKB/TrEMBL

A9J7N9, Q9VLC5

Related

FBpp0079406

Conserved Domains (2) summary

cd07141
Location:34 → 514

ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

PLN02466
Location:9 → 512

PLN02466; aldehyde dehydrogenase family 2 member
NM_001273361.1 → NP_001260290.1 aldehyde dehydrogenase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260290.1

Status: REVIEWED

UniProtKB/TrEMBL

A9J7N9, Q9VLC5

Conserved Domains (2) summary

cd07141
Location:34 → 514

ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

PLN02466
Location:9 → 512

PLN02466; aldehyde dehydrogenase family 2 member