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    tbc trabuco [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318059, updated on 17-Dec-2024

    Summary

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    Official Symbol
    tbcprovided by FlyBase
    Official Full Name
    trabucoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052506
    Locus tag
    Dmel_CG32506
    See related
    AllianceGenome:FB:FBgn0052506
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32506; Dmel\CG32506
    Summary
    Predicted to enable GTPase activator activity. Involved in protein secretion. Located in endoplasmic reticulum exit site. Orthologous to human SGSM1 (small G protein signaling modulator 1) and SGSM2 (small G protein signaling modulator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tbc in Genome Data Viewer
    Location:
    19D1-19D1; 1-64 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20449331..20467065)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20320358..20338092)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rho GTPase activating protein at 19D Neighboring gene Glutathione S transferase T3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article
    2. Evi5 promotes collective cell migration through its Rab-GAP activity. Laflamme C, et al. J Cell Biol, 2012 Jul 9. PMID 22778279, Free PMC Article
    3. Population- and sex-biased gene expression in the excretion organs of Drosophila melanogaster. Huylmans AK, et al. G3 (Bethesda), 2014 Sep 22. PMID 25246242, Free PMC Article
    4. Collagen secretion screening in Drosophila supports a common secretory machinery and multiple Rab requirements. Ke H, et al. J Genet Genomics, 2018 Jun 1. PMID 29935791
    5. Genetic architecture of natural variation of cardiac performance from flies to humans. Saha S, et al. Elife, 2022 Nov 16. PMID 36383075, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: 20453792-20453846 mobile_element_type = transposon:INE-1{}4943

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trabuco
    Names
    CG32506-PC
    CG32506-PD
    tbc-PC
    tbc-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      20449331..20467065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298565.1 → NP_001285494.1  trabuco, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285494.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZD0, Q8IQ30
      Conserved Domains (3) summary
      smart00164
      Location:923 → 1087
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd15784
      Location:292 → 466
      PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
      pfam02759
      Location:45 → 218
      RUN; RUN domain

    2. NM_134551.7 → NP_608395.6  trabuco, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608395.6

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZD0, Q8IQ30
      Conserved Domains (3) summary
      smart00164
      Location:923 → 1087
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd15784
      Location:292 → 466
      PH_RUTBC; Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins
      pfam02759
      Location:45 → 218
      RUN; RUN domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQ30 Q8IQ30

    Gene LinkOut

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