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    Efr ER GDP-fucose transporter [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31553, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Efrprovided by FlyBase
    Official Full Name
    ER GDP-fucose transporterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029849
    Locus tag
    Dmel_CG3774
    See related
    AllianceGenome:FB:FBgn0029849
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3774; Dmel\CG3774; efr
    Summary
    Enables GDP-fucose transmembrane transporter activity; UDP-N-acetylglucosamine transmembrane transporter activity; and UDP-xylose transmembrane transporter activity. Involved in glycoprotein biosynthetic process and nucleotide-sugar transmembrane transport. Is active in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human SLC35B4 (solute carrier family 35 member B4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Efr in Genome Data Viewer
    Location:
    5E1-5E1; 1-16 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6219957..6222719)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6113990..6116752)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene vanin-like Neighboring gene Biotinidase Neighboring gene spaghetti squash Neighboring gene detonator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two pathways for importing GDP-fucose into the endoplasmic reticulum lumen function redundantly in the O-fucosylation of Notch in Drosophila. Ishikawa HO, et al. J Biol Chem, 2010 Feb 5. PMID 19948734, Free PMC Article
    2. Rescue of Notch signaling in cells incapable of GDP-L-fucose synthesis by gap junction transfer of GDP-L-fucose in Drosophila. Ayukawa T, et al. Proc Natl Acad Sci U S A, 2012 Sep 18. PMID 22949680, Free PMC Article
    3. Identification and characterization of a novel Drosophila 3'-phosphoadenosine 5'-phosphosulfate transporter. Goda E, et al. J Biol Chem, 2006 Sep 29. PMID 16873373
    4. The N's and O's of Drosophila glycoprotein glycobiology. Katoh T, et al. Glycoconj J, 2013 Jan. PMID 22936173, Free PMC Article
    5. Metabolic disruption in Drosophila bang-sensitive seizure mutants. Fergestad T, et al. Genetics, 2006 Jul. PMID 16648587, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Drosophila CG3774 gene has been identified as a putative ortholog of human SLC35B4, which encodes a UDP-GlcNAc/UDP-xylose transporter, and was called as Efr (ER GDP-fucose transporter).
      Title: Two pathways for importing GDP-fucose into the endoplasmic reticulum lumen function redundantly in the O-fucosylation of Notch in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables CMP-N-acetylneuraminate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP-fucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables GDP-mannose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-N-acetylglucosamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-N-acetylglucosamine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-N-acetylglucosamine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables UDP-glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables UDP-glucuronic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-xylose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-xylose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-xylose transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in CMP-N-acetylneuraminate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GDP-fucose import into endoplasmic reticulum lumen IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in GDP-fucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in GDP-mannose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-N-acetylglucosamine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-N-acetylglucosamine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-N-acetylglucosamine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in UDP-glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in UDP-glucuronic acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-xylose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-xylose transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked fucosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ER GDP-fucose transporter
    Names
    CG3774-PA
    CG3774-PB
    ER GFP-fucose transporter
    Efr-PA
    Efr-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6219957..6222719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132071.3 → NP_572299.1  ER GDP-fucose transporter, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572299.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5BIK7, Q9W429
      UniProtKB/TrEMBL
      A4V408
      Related
      FBpp0070839
      Conserved Domains (2) summary
      pfam08449
      Location:6 → 325
      UAA; UAA transporter family
      cl23754
      Location:91 → 321
      EamA; EamA-like transporter family

    2. NM_167062.3 → NP_727071.1  ER GDP-fucose transporter, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727071.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5BIK7, Q9W429
      UniProtKB/TrEMBL
      A4V408
      Related
      FBpp0070840
      Conserved Domains (2) summary
      pfam08449
      Location:6 → 325
      UAA; UAA transporter family
      cl23754
      Location:91 → 321
      EamA; EamA-like transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V408 A4V408
    Q9W429.1 Q9W429

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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