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    nenya nenya [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318572, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nenyaprovided by FlyBase
    Official Full Name
    nenyaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051053
    Locus tag
    Dmel_CG31053
    See related
    AllianceGenome:FB:FBgn0051053
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31053; Dmel\CG31053; Nenya
    Summary
    Predicted to enable SUMO transferase activity and zinc ion binding activity. Involved in positive regulation of meiotic DNA double-strand break formation. Predicted to be located in chromosome. Predicted to be active in synaptonemal complex. Orthologous to human RNF212B (ring finger protein 212B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nenya in Genome Data Viewer
    Location:
    98B6-98B6; 3-94 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27927357..27928174, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23753079..23753896, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene long non-coding RNA:CR45566 Neighboring gene Ribosomal protein L4 Neighboring gene minotaur Neighboring gene antisense RNA:CR46452 Neighboring gene Nuclear receptor binding SET domain protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A pathogenic variant in the uncharacterized RNF212B gene results in severe aneuploidy male infertility and repeated IVF failure. Gershoni M, et al. HGG Adv, 2023 Jul 13. PMID 37124137, Free PMC Article
    2. Narya, a RING finger domain-containing protein, is required for meiotic DNA double-strand break formation and crossover maturation in Drosophila melanogaster. Lake CM, et al. PLoS Genet, 2019 Jan. PMID 30615609, Free PMC Article
    3. Minotaur is critical for primary piRNA biogenesis. Vagin VV, et al. RNA, 2013 Aug. PMID 23788724, Free PMC Article
    4. SnapShot: Meiosis - Prophase I. Láscarez-Lagunas L, et al. Cell, 2020 Jun 11. PMID 32531249
    5. A transcriptomics-based RNAi screen for regulators of meiosis and early stages of oocyte development in Drosophila melanogaster. Hughes SE, et al. G3 (Bethesda), 2024 Apr 3. PMID 38333961, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SUMO transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in homologous chromosome pairing at meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of meiotic DNA double-strand break formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in synaptonemal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptonemal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nenya
    Names
    CG31053-PA
    nenya-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27927357..27928174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170357.3 → NP_733236.1  nenya [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733236.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IMM9
      Related
      FBpp0084637
      Conserved Domains (1) summary
      pfam14634
      Location:5 → 49
      zf-RING_5; zinc-RING finger domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IMM9.1 Q8IMM9

    Gene LinkOut

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