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    CNT2 Concentrative nucleoside transporter 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35914, updated on 9-Dec-2024

    Summary

    Official Symbol
    CNT2provided by FlyBase
    Official Full Name
    Concentrative nucleoside transporter 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0025709
    Locus tag
    Dmel_CG8083
    See related
    AllianceGenome:FB:FBgn0025709
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:CK00459; CG8083; CK00459; DmCnt2; Dmel\CG8083
    Summary
    Enables cyclic-di-GMP transmembrane transporter activity. Involved in positive regulation of cGAS/STING signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; amnioserosa; gut section; and yolk nucleus. Orthologous to several human genes including SLC28A1 (solute carrier family 28 member 1) and SLC28A2 (solute carrier family 28 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See CNT2 in Genome Data Viewer
    Location:
    45A1-45A1; 2-60 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9078721..9082374)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4966226..4969879)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene anachronism Neighboring gene antisense RNA:CR45924 Neighboring gene Concentrative nucleoside transporter 1 Neighboring gene uncharacterized protein Neighboring gene DEAD box protein 45A Neighboring gene NAD kinase 2, mitochondrial

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in membrane  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    concentrative nucleoside transporter 2
    Names
    CG8083-PA
    CG8083-PB
    CG8083-PC
    CNT2-PA
    CNT2-PB
    CNT2-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9078721..9082374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136602.5 → NP_610446.1  concentrative nucleoside transporter 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610446.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDP6, Q7K4A1
      Related
      FBpp0087643
      Conserved Domains (4) summary
      TIGR00804
      Location:180 → 578
      nupC; nucleoside transporter
      pfam01773
      Location:187 → 254
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:368 → 578
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:268 → 363
      Gate; Nucleoside recognition
    2. NM_206059.3 → NP_995781.1  concentrative nucleoside transporter 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995781.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDP6, Q7K4A1
      Conserved Domains (4) summary
      TIGR00804
      Location:180 → 578
      nupC; nucleoside transporter
      pfam01773
      Location:187 → 254
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:368 → 578
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:268 → 363
      Gate; Nucleoside recognition
    3. NM_206060.3 → NP_995782.1  concentrative nucleoside transporter 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995782.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7N2, F3YDP6
      Conserved Domains (4) summary
      TIGR00804
      Location:179 → 577
      nupC; nucleoside transporter
      pfam01773
      Location:186 → 253
      Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
      pfam07662
      Location:367 → 577
      Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
      pfam07670
      Location:267 → 362
      Gate; Nucleoside recognition
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