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    PIG-S Phosphatidylinositol glycan anchor biosynthesis class S [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42979, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIG-Sprovided by FlyBase
    Official Full Name
    Phosphatidylinositol glycan anchor biosynthesis class Sprovided by FlyBase
    Primary source
    FLYBASE:FBgn0265190
    Locus tag
    Dmel_CG44255
    See related
    AllianceGenome:FB:FBgn0265190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13644; CG31120; CG44255; CG6031; Dmel\CG44255; PIGS; sud2
    Summary
    Involved in GPI anchor biosynthetic process and rhabdomere membrane biogenesis. Located in endomembrane system and nucleoplasm. Part of GPI-anchor transamidase complex. Is active in endoplasmic reticulum and nuclear membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; and spermatozoon. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 95. Orthologous to human PIGS (phosphatidylinositol glycan anchor biosynthesis class S). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PIG-S in Genome Data Viewer
    Location:
    96B6-96B6; 3-86 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24913216..24917864, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20738938..20743586, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44267 Neighboring gene transfer RNA:Aspartic acid-GTC 1-12 Neighboring gene transfer RNA:Aspartic acid-GTC 3-1 Neighboring gene sudestada1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46097 Neighboring gene Mitotic spindle and nuclear protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stability of the transamidase complex catalyzing GPI anchoring of proteins. Kawaguchi K, et al. Biochem Biophys Res Commun, 2019 May 7. PMID 30914202
    2. Subunits of the GPI transamidase complex localize to the endoplasmic reticulum and nuclear envelope in Drosophila. Kawaguchi K, et al. FEBS Lett, 2021 Apr. PMID 33496978
    3. Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth. Katz MJ, et al. Proc Natl Acad Sci U S A, 2014 Mar 18. PMID 24550463, Free PMC Article
    4. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
    5. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in attachment of GPI anchor to protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of GPI anchor to protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rhabdomere membrane biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GPI-anchor transamidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GPI-anchor transamidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of GPI-anchor transamidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm HDA PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol glycan anchor biosynthesis class S
    Names
    CG44255-PC
    PIG-S-PC
    phosphatidylinositol glycan anchor biosynthesis, class S
    phosphatidylinositol glycan anchor biosynthesis, class S ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24913216..24917864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170181.3 → NP_733060.1  phosphatidylinositol glycan anchor biosynthesis class S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733060.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A3W8, Q95R26, Q9VC10
      Related
      FBpp0308257
      Conserved Domains (1) summary
      pfam10510
      Location:28 → 521
      PIG-S; Phosphatidylinositol-glycan biosynthesis class S protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VC10 Q9VC10

    Gene LinkOut

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