Slh SLY-1 homologous [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Slhprovided by FlyBase
Official Full Name: SLY-1 homologousprovided by FlyBase
Primary source: FLYBASE:FBgn0264978
Locus tag: Dmel_CG3539
See related: AllianceGenome:FB:FBgn0264978
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15393; CG3539; d-sly; Dmel\CG3539; slh; SLH; Sly; Sly1; SLY1; Sly1p
Old locus tag: Dmel_CG15393
Summary: Predicted to enable syntaxin binding activity. Involved in wing disc dorsal/ventral pattern formation. Predicted to be located in Golgi-associated vesicle; cis-Golgi network; and plasma membrane. Predicted to be active in Golgi membrane. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gland; and gut section. Orthologous to human SCFD1 (sec1 family domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (2488197..2492671, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (2488197..2492671, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables SNARE binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein-containing complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables syntaxin binding	IBA Inferred from Biological aspect of Ancestor more info
enables syntaxin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-Golgi vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ER to Golgi vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to toxic substance	ISS Inferred from Sequence or Structural Similarity more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in wing disc dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi-associated vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cis-Golgi network	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

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The following sections contain reference sequences that belong to a specific genome build. Explain