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    Sld5 Sld5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43166, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sld5provided by FlyBase
    Official Full Name
    Sld5provided by FlyBase
    Primary source
    FLYBASE:FBgn0039403
    Locus tag
    Dmel_CG14549
    See related
    AllianceGenome:FB:FBgn0039403
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0172774.61; CG14549; Dmel\CG14549; SLD5
    Summary
    Involved in mitotic cell cycle. Part of CMG complex and GINS complex. Orthologous to human GINS4 (GINS complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sld5 in Genome Data Viewer
    Location:
    96F10-96F10; 3-89 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26055657..26056547, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21881379..21882269, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting 2 Neighboring gene Cytidine/uridine monophosphate kinase 1 Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class P Neighboring gene Threonyl-carbamoyl synthesis 6 Neighboring gene Ribosomal protein L34a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Sld5 is essential for normal cell cycle progression and maintenance of genomic integrity. Gouge CA, et al. Biochem Biophys Res Commun, 2010 Sep 10. PMID 20709026, Free PMC Article
    2. Comparing zinc finger nucleases and transcription activator-like effector nucleases for gene targeting in Drosophila. Beumer KJ, et al. G3 (Bethesda), 2013 Oct 3. PMID 23979928, Free PMC Article
    3. The mechanism of DNA unwinding by the eukaryotic replicative helicase. Burnham DR, et al. Nat Commun, 2019 May 14. PMID 31089141, Free PMC Article
    4. Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase. Kose HB, et al. Nat Commun, 2020 Jul 24. PMID 32709841, Free PMC Article
    5. Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Moyer SE, et al. Proc Natl Acad Sci U S A, 2006 Jul 5. PMID 16798881, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in DNA replication initiation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CMG complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of GINS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GINS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sld5
    Names
    CG14549-PA
    Sld5-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26055657..26056547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143200.4 → NP_651457.1  Sld5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651457.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YD43, Q9VBI1
      Related
      FBpp0084348
      Conserved Domains (2) summary
      cd11711
      Location:38 → 156
      GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5
      cd21692
      Location:175 → 228
      GINS_B_Sld5; beta-strand (B) domain of GINS complex protein Sld5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBI1 Q9VBI1

    Gene LinkOut

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