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    Vps53 Vacuolar protein sorting 53 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33640, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vps53provided by FlyBase
    Official Full Name
    Vacuolar protein sorting 53provided by FlyBase
    Primary source
    FLYBASE:FBgn0031598
    Locus tag
    Dmel_CG3338
    See related
    AllianceGenome:FB:FBgn0031598
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3338; Dmel\CG3338
    Summary
    Predicted to be involved in endocytic recycling and retrograde transport, endosome to Golgi. Predicted to be located in Golgi apparatus. Predicted to be part of GARP complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2E. Orthologous to human VPS53 (VPS53 subunit of GARP complex). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vps53 in Genome Data Viewer
    Location:
    24E4-24E4; 2-12 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4382925..4386062, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4382925..4386062, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45363 Neighboring gene TNF-receptor-associated factor 4 Neighboring gene uncharacterized protein Neighboring gene Partner of Sld Five 2 Neighboring gene Trehalose-6-phosphate synthase 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling. O'Brien CE, et al. J Cell Biol, 2023 Jan 2. PMID 36239632, Free PMC Article
    2. Developmental program-independent secretory granule degradation in larval salivary gland cells of Drosophila. Csizmadia T, et al. Traffic, 2022 Dec. PMID 36353974, Free PMC Article
    3. The small G protein Arl5 contributes to endosome-to-Golgi traffic by aiding the recruitment of the GARP complex to the Golgi. Rosa-Ferreira C, et al. Biol Open, 2015 Mar 20. PMID 25795912, Free PMC Article
    4. Model system identification of novel congenital heart disease gene candidates: focus on RPL13. Schroeder AM, et al. Hum Mol Genet, 2019 Dec 1. PMID 31625562, Free PMC Article
    5. The vacuolar protein sorting genes in insects: A comparative genome view. Li Z, et al. Insect Biochem Mol Biol, 2015 Jul. PMID 25486452

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GARP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GARP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of GARP complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting 53
    Names
    CG3338-PA
    Vps53-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4382925..4386062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134981.3 → NP_608825.2  vacuolar protein sorting 53 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608825.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQY8
      Related
      FBpp0077151
      Conserved Domains (1) summary
      pfam04100
      Location:42 → 434
      Vps53_N; Vps53-like, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TS1 Q95TS1
    Q9VQY8 Q9VQY8

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