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    CG1640 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32292, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1640provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030478
    Locus tag
    Dmel_CG1640
    See related
    AllianceGenome:FB:FBgn0030478
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ALT; cg1640; Dmel\CG1640
    Summary
    Enables L-alanine:2-oxoglutarate aminotransferase activity. Involved in pyruvate metabolic process. Located in cytosol and mitochondrion. Is expressed in several structures, including adult brain; adult neuromere; ganglia; germline cell; and synaptic neuropil domain. Used to study amino acid metabolic disorder. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spastic paraplegia and microcephaly. Orthologous to human GPT (glutamic--pyruvic transaminase) and GPT2 (glutamic--pyruvic transaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1640 in Genome Data Viewer
    Location:
    11F1-11F1; 1-43 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13370606..13380160)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13264639..13274193)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Synaptotagmin 12 Neighboring gene doublesex-Mab related 11E Neighboring gene Rbp1-like Neighboring gene Tim9a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Independent Effects of γ-Aminobutyric Acid Transaminase (GABAT) on Metabolic and Sleep Homeostasis. Maguire SE, et al. J Biol Chem, 2015 Aug 14. PMID 26124278, Free PMC Article
    2. Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila. Rabah Y, et al. Nat Metab, 2023 Nov. PMID 37932430, Free PMC Article
    3. Sperm-Leucylaminopeptidases are required for male fertility as structural components of mitochondrial paracrystalline material in Drosophila melanogaster sperm. Laurinyecz B, et al. PLoS Genet, 2019 Feb. PMID 30802236, Free PMC Article
    4. Glial metabolism versatility regulates mushroom body-driven behavioral output in Drosophila. Basu R, et al. Learn Mem, 2024 May. PMID 38862167, Free PMC Article
    5. Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases. Schulz C, et al. Dev Genes Evol, 2001 Dec. PMID 11819115

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-alanine:2-oxoglutarate aminotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-alanine:2-oxoglutarate aminotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in L-alanine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pyruvate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1640-PA
    CG1640-PB
    CG1640-PC
    CG1640-PD
    CG1640-PE
    CG1640-PF
    CG1640-PG
    alanine aminotransferase
    NP_001285206.1
    NP_572879.2
    NP_727696.2
    NP_727697.1
    NP_727698.1
    NP_727699.1
    NP_727700.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13370606..13380160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167365.1 → NP_727696.2  uncharacterized protein Dmel_CG1640, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727696.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T9D5, Q9VYD9
      Related
      FBpp0073600, FBtr0073769
      Conserved Domains (2) summary
      cd00609
      Location:178 → 564
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PTZ00377
      Location:99 → 575
      PTZ00377; alanine aminotransferase; Provisional

    2. NM_167369.2 → NP_727700.1  uncharacterized protein Dmel_CG1640, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727700.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KV27, Q8T9D5
      Related
      FBpp0073605
      Conserved Domains (2) summary
      cd00609
      Location:171 → 557
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PTZ00377
      Location:92 → 568
      PTZ00377; alanine aminotransferase; Provisional

    3. NM_132651.3 → NP_572879.2  uncharacterized protein Dmel_CG1640, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572879.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KV27, Q8T9D5
      Related
      FBpp0073604
      Conserved Domains (2) summary
      cd00609
      Location:171 → 557
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PTZ00377
      Location:92 → 568
      PTZ00377; alanine aminotransferase; Provisional

    4. NM_167366.2 → NP_727697.1  uncharacterized protein Dmel_CG1640, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727697.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KV27, Q8T9D5
      Related
      FBpp0073601
      Conserved Domains (2) summary
      cd00609
      Location:171 → 557
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PTZ00377
      Location:92 → 568
      PTZ00377; alanine aminotransferase; Provisional

    5. NM_167367.2 → NP_727698.1  uncharacterized protein Dmel_CG1640, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727698.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KV27, Q8T9D5
      Related
      FBpp0073602
      Conserved Domains (2) summary
      cd00609
      Location:171 → 557
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PTZ00377
      Location:92 → 568
      PTZ00377; alanine aminotransferase; Provisional

    6. NM_167368.2 → NP_727699.1  uncharacterized protein Dmel_CG1640, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727699.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KV27, Q8T9D5
      Related
      FBpp0073603
      Conserved Domains (2) summary
      cd00609
      Location:171 → 557
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PTZ00377
      Location:92 → 568
      PTZ00377; alanine aminotransferase; Provisional

    7. NM_001298277.1 → NP_001285206.1  uncharacterized protein Dmel_CG1640, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285206.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KV27, Q8T9D5
      Conserved Domains (2) summary
      cd00609
      Location:171 → 557
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PTZ00377
      Location:92 → 568
      PTZ00377; alanine aminotransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KV27 Q7KV27
    Q8T9D5 Q8T9D5
    Q9VYD9 Q9VYD9

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