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    Fatp2 Fatty acid transport protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37657, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fatp2provided by FlyBase
    Official Full Name
    Fatty acid transport protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0265187
    Locus tag
    Dmel_CG44252
    See related
    AllianceGenome:FB:FBgn0265187
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30194; CG44252; Dmel\CG44252; SLC27A1/4; SLC27A2
    Summary
    Predicted to enable long-chain fatty acid transmembrane transporter activity; long-chain fatty acid-CoA ligase activity; and very long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid import into cell and long-chain fatty acid metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Is expressed in several structures, including adult head; embryonic antennal sense organ; embryonic epipharynx; epithelium; and sensory cluster. Used to study metabolic dysfunction-associated steatotic liver disease. Orthologous to human SLC27A1 (solute carrier family 27 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fatp2 in Genome Data Viewer
    Location:
    59C2-59C2; 2-102 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23055474..23061549)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18942997..18949072)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene twist Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dynactin 3, p24 subunit Neighboring gene uncharacterized protein Neighboring gene Prophenoloxidase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity. Pozo-Morales M, et al. Life Sci Alliance, 2024 May. PMID 38467419, Free PMC Article
    2. Fatty acid transport proteins in disease: New insights from invertebrate models. Dourlen P, et al. Prog Lipid Res, 2015 Oct. PMID 26416577
    3. Mammalian puberty: a fly perspective. Guirado J, et al. FEBS J, 2023 Jan. PMID 35607827, Free PMC Article
    4. Body-fat sensor triggers ribosome maturation in the steroidogenic gland to initiate sexual maturation in Drosophila. Juarez-Carreño S, et al. Cell Rep, 2021 Oct 12. PMID 34644570
    5. Gene activation by dCas9-CBP and the SAM system differ in target preference. Sajwan S, et al. Sci Rep, 2019 Dec 2. PMID 31792240, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables fatty acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables long-chain fatty acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables very long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in long-chain fatty acid import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid transport protein 2
    Names
    CG44252-PB
    CG44252-PD
    CG44252-PE
    Fatp2-PB
    Fatp2-PD
    Fatp2-PE
    NP_611749.2
    NP_995925.2
    NP_995926.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23055474..23061549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206203.2 → NP_995925.2  fatty acid transport protein 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995925.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVJ6
      Conserved Domains (2) summary
      PRK08279
      Location:115 → 714
      PRK08279; long-chain-acyl-CoA synthetase; Validated
      cl17068
      Location:163 → 680
      AFD_class_I; Adenylate forming domain, Class I superfamily

    2. NM_206204.3 → NP_995926.1  fatty acid transport protein 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995926.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVJ6
      Conserved Domains (2) summary
      PRK08279
      Location:115 → 714
      PRK08279; long-chain-acyl-CoA synthetase; Validated
      cl17068
      Location:163 → 680
      AFD_class_I; Adenylate forming domain, Class I superfamily

    3. NM_137905.5 → NP_611749.2  fatty acid transport protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611749.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1W0
      Related
      FBpp0308255
      Conserved Domains (2) summary
      PRK08279
      Location:104 → 703
      PRK08279; long-chain-acyl-CoA synthetase; Validated
      cl17068
      Location:152 → 669
      AFD_class_I; Adenylate forming domain, Class I superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KVJ6 Q7KVJ6
    Q9W1W0 Q9W1W0

    Gene LinkOut

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