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    Cad88C Cadherin 88C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41774, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cad88Cprovided by FlyBase
    Official Full Name
    Cadherin 88Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038247
    Locus tag
    Dmel_CG3389
    See related
    AllianceGenome:FB:FBgn0038247
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cad88C; CG3389; CT11389; DCad88C; Dm Cad88C; Dmel\CG3389
    Summary
    Predicted to enable calcium ion binding activity. Involved in open tracheal system development. Predicted to be active in plasma membrane. Is expressed in main body follicle cell; polar follicle cell; and spiracular chamber. Orthologous to human CDHR2 (cadherin related family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cad88C in Genome Data Viewer
    Location:
    88C10-88C10; 3-55 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14630478..14641776)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10456200..10467498)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene punt Neighboring gene Histone H4 replacement Neighboring gene uncharacterized protein Neighboring gene lethal (3) L1231 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expressing a moth abcc2 gene in transgenic Drosophila causes susceptibility to Bt Cry1Ac without requiring a cadherin-like protein receptor. Stevens T, et al. Insect Biochem Mol Biol, 2017 Jan. PMID 27914919
    2. PDZ-domain-binding sites are common among cadherins. Demontis F, et al. Dev Genes Evol, 2006 Nov. PMID 17021864
    3. Hedgehog and Dpp signaling induce cadherin Cad86C expression in the morphogenetic furrow during Drosophila eye development. Schlichting K, et al. Mech Dev, 2008 Aug. PMID 18539010
    4. Reiterative use of signalling pathways controls multiple cellular events during Drosophila posterior spiracle organogenesis. Maurel-Zaffran C, et al. Dev Biol, 2010 Jul 1. PMID 20403348
    5. Cadherins in embryonic and neural morphogenesis. Tepass U, et al. Nat Rev Mol Cell Biol, 2000 Nov. PMID 11253370

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in open tracheal system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cadherin 88C
    Names
    CG3389-PB
    Cad88C-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14630478..14641776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169594.3 → NP_731930.3  cadherin 88C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731930.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFH5
      Conserved Domains (2) summary
      cd11304
      Location:1090 → 1191
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:1221 → 1302
      CA; Cadherin repeats
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFH5 Q9VFH5

    Gene LinkOut

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