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    zda zonda [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37144, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zdaprovided by FlyBase
    Official Full Name
    zondaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034368
    Locus tag
    Dmel_CG5482
    See related
    AllianceGenome:FB:FBgn0034368
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5482; Dmel\CG5482; Zda
    Summary
    Predicted to enable protein folding chaperone. Involved in macroautophagy and response to starvation. Located in cytosol; omegasome; and vacuole. Is expressed in adult head; adult heart; and organism. Orthologous to human FKBP8 (FKBP prolyl isomerase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See zda in Genome Data Viewer
    Location:
    55E2-55E3; 2-86 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18629594..18632045, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14517099..14519550, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Secretory 6 Neighboring gene Cystathionine gamma-lyase Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Tryptophan-CCA 2-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The immunophilin Zonda controls regulated exocytosis in endocrine and exocrine tissues. de la Riva-Carrasco R, et al. Traffic, 2021 Apr. PMID 33336828
    2. Autophagic paintings: In the frontier of art and science. Valko A. Autophagy, 2019 Nov. PMID 31455131, Free PMC Article
    3. Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster. Ghartey-Kwansah G, et al. BMC Dev Biol, 2018 Mar 27. PMID 29587629, Free PMC Article
    4. shutdown is a component of the Drosophila piRNA biogenesis machinery. Preall JB, et al. RNA, 2012 Aug. PMID 22753781, Free PMC Article
    5. Zonda is a novel early component of the autophagy pathway in Drosophila. Melani M, et al. Mol Biol Cell, 2017 Nov 1. PMID 28904211, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in autolysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in omegasome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zonda
    Names
    CG5482-PA
    CG5482-PB
    CG5482-PC
    CG5482-PD
    zda-PA
    zda-PB
    zda-PC
    zda-PD
    NP_001286579.1
    NP_001286580.1
    NP_001286581.1
    NP_611353.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18629594..18632045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299651.1 → NP_001286580.1  zonda, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286580.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3D4
      Conserved Domains (3) summary
      sd00006
      Location:196 → 220
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:80 → 172
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13414
      Location:255 → 318
      TPR_11; TPR repeat

    2. NM_001299652.1 → NP_001286581.1  zonda, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286581.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3D4
      Conserved Domains (3) summary
      sd00006
      Location:196 → 220
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:80 → 172
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13414
      Location:255 → 318
      TPR_11; TPR repeat

    3. NM_137509.4 → NP_611353.1  zonda, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611353.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3D4
      Related
      FBpp0085842
      Conserved Domains (3) summary
      sd00006
      Location:196 → 220
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:80 → 172
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13414
      Location:255 → 318
      TPR_11; TPR repeat

    4. NM_001299650.1 → NP_001286579.1  zonda, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286579.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K3D4
      Conserved Domains (3) summary
      sd00006
      Location:196 → 220
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:80 → 172
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13414
      Location:255 → 318
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K3D4 Q7K3D4

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