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    Cbs Cystathionine beta-synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33081, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cbsprovided by FlyBase
    Official Full Name
    Cystathionine beta-synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031148
    Locus tag
    Dmel_CG1753
    See related
    AllianceGenome:FB:FBgn0031148
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cbs; CBS; CG1753; Csb; dCBS; DmCBS; Dmel\CG1753
    Summary
    Predicted to enable cystathionine beta-synthase activity and nitrite reductase (NO-forming) activity. Involved in determination of adult lifespan. Predicted to be active in cytoplasm. Is expressed in embryonic midgut chamber; embryonic/larval midgut; gastric caecum; and organism. Used to study homocystinuria. Human ortholog(s) of this gene implicated in several diseases, including cerebral infarction; homocystinuria; hyperhomocysteinemia; malaria; and neural tube defect. Orthologous to human CBS (cystathionine beta-synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Cbs in Genome Data Viewer
    Location:
    19E7-19E7; 1-65 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21045138..21049096)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20916165..20920123)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Nuclear transport factor-2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44431 Neighboring gene Microsomal glutathione S-transferase-like Neighboring gene ncRNA Neighboring gene small Cajal body-specific RNA : MeU2-C28 Neighboring gene Catalytic subunit 3A of the oligosaccharyltransferase complex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase. Koutmos M, et al. Proc Natl Acad Sci U S A, 2010 Dec 7. PMID 21081698, Free PMC Article
    2. Cystathionine β-synthase Deficiency Impairs Vision in the Fruit Fly, Drosophila melanogaster. Flores-Flores M, et al. Curr Eye Res, 2021 Apr. PMID 32865440
    3. Comparative study of enzyme activity and heme reactivity in Drosophila melanogaster and Homo sapiens cystathionine β-synthases. Su Y, et al. Biochemistry, 2013 Jan 29. PMID 23002992, Free PMC Article
    4. Increased transsulfuration mediates longevity and dietary restriction in Drosophila. Kabil H, et al. Proc Natl Acad Sci U S A, 2011 Oct 4. PMID 21930912, Free PMC Article
    5. Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of Drosophila melanogaster. Shaposhnikov MV, et al. Mech Ageing Dev, 2022 Apr. PMID 35247392

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletions of the cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of Drosophila melanogaster.
      Title: Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of Drosophila melanogaster.
    2. This study showed that transgene overexpression of the CSE and CBS in Drosophila induce similar effects on stress-resistance and locomotor activity, however lifespan extending effect was revealed for CBS overexpression only.
      Title: Overexpression of CBS and CSE genes affects lifespan, stress resistance and locomotor activity in Drosophila melanogaster.
    3. The Fe(II) heme in DmCBS is less stable than that in human CBS, undergoing more facile reoxidation and ligand exchange.
      Title: Comparative study of enzyme activity and heme reactivity in Drosophila melanogaster and Homo sapiens cystathionine β-synthases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cystathionine beta-synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cystathionine beta-synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nitrite reductase (NO-forming) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cysteine biosynthetic process from serine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cysteine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cysteine biosynthetic process via cystathionine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homocysteine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to endoplasmic reticulum stress HMP PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cystathionine beta-synthase
    Names
    CG1753-PA
    CG1753-PB
    CG1753-PC
    Cbs-PA
    Cbs-PB
    Cbs-PC
    cystathionine &grb;-synthase
    cystathionine beta synthase
    cystathionine-beta-synthase
    NP_001285508.1
    NP_608424.1
    NP_728384.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21045138..21049096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134580.3 → NP_608424.1  cystathionine beta-synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608424.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRD9
      Related
      FBpp0076937
      Conserved Domains (3) summary
      cd01561
      Location:54 → 352
      CBS_like; CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. ...
      cd04608
      Location:386 → 504
      CBS_pair_PALP_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well ...
      TIGR01137
      Location:45 → 505
      cysta_beta; cystathionine beta-synthase

    2. NM_001298579.1 → NP_001285508.1  cystathionine beta-synthase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285508.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRD9
      Conserved Domains (3) summary
      cd01561
      Location:54 → 352
      CBS_like; CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. ...
      cd04608
      Location:386 → 504
      CBS_pair_PALP_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well ...
      TIGR01137
      Location:45 → 505
      cysta_beta; cystathionine beta-synthase

    3. NM_167726.2 → NP_728384.1  cystathionine beta-synthase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728384.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRD9
      Related
      FBpp0076938
      Conserved Domains (3) summary
      cd01561
      Location:54 → 352
      CBS_like; CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. ...
      cd04608
      Location:386 → 504
      CBS_pair_PALP_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well ...
      TIGR01137
      Location:45 → 505
      cysta_beta; cystathionine beta-synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRD9 Q9VRD9

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