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    CG1983 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43588, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1983provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039751
    Locus tag
    Dmel_CG1983
    See related
    AllianceGenome:FB:FBgn0039751
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG1983
    Summary
    Predicted to enable pyridoxal phosphate binding activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in early-onset vitamin B6-dependent epilepsy 1. Orthologous to human PLPBP (pyridoxal phosphate binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1983 in Genome Data Viewer
    Location:
    99E1-99E1; 3-100 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30175786..30177700, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26001508..26003422, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Related to Sod Neighboring gene Myosin light chain 2 Neighboring gene uncharacterized protein Neighboring gene Blocked early in transport 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mosaic genetic screen for suppressors of the de2f1 mutant phenotype in Drosophila. Ambrus AM, et al. Genetics, 2009 Sep. PMID 19546319, Free PMC Article
    2. A temporal map of transcription factor activity: mef2 directly regulates target genes at all stages of muscle development. Sandmann T, et al. Dev Cell, 2006 Jun. PMID 16740481
    3. A genetic interaction map of cell cycle regulators. Billmann M, et al. Mol Biol Cell, 2016 Apr 15. PMID 26912791, Free PMC Article
    4. Latitudinal clines in gene expression and cis-regulatory element variation in Drosophila melanogaster. Juneja P, et al. BMC Genomics, 2016 Nov 28. PMID 27894253, Free PMC Article
    5. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in vitamin B6 metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1983-PA
    CG1983-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30175786..30177700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300673.1 → NP_001287602.1  uncharacterized protein Dmel_CG1983, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287602.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P39, Q9VA97
      Conserved Domains (1) summary
      cd06822
      Location:15 → 248
      PLPDE_III_YBL036c_euk; Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Eukaryotic YBL036c-like proteins

    2. NM_143519.3 → NP_651776.2  uncharacterized protein Dmel_CG1983, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651776.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P39, Q9VA97
      Related
      FBpp0084940
      Conserved Domains (1) summary
      cd06822
      Location:15 → 248
      PLPDE_III_YBL036c_euk; Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Eukaryotic YBL036c-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VA97 Q9VA97

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