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    stol stolid [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34921, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stolprovided by FlyBase
    Official Full Name
    stolidprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028863
    Locus tag
    Dmel_CG4587
    See related
    AllianceGenome:FB:FBgn0028863
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS07108.2; CG4587; Dmel\CG4587; DS07108.2; mdcds_3066
    Summary
    Predicted to enable voltage-gated calcium channel activity. Involved in regulation of dendrite development. Predicted to be part of voltage-gated calcium channel complex. Is expressed in adult head and spermatozoon. Orthologous to human CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See stol in Genome Data Viewer
    Location:
    35D3-35D3; 2-51 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15644183..15718272, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15644183..15718272, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cyclin E Neighboring gene long non-coding RNA:CR44974 Neighboring gene antisense RNA:CR44866

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Different functions of two putative Drosophila α(2)δ subunits in the same identified motoneurons. Heinrich L, et al. Sci Rep, 2020 Aug 13. PMID 32792569, Free PMC Article
    2. Proteome-Wide Analysis of ADAR-Mediated Messenger RNA Editing during Fruit Fly Ontogeny. Kliuchnikova AA, et al. J Proteome Res, 2020 Oct 2. PMID 32866021
    3. Transcription factor Acj6 controls dendrite targeting via a combinatorial cell-surface code. Xie Q, et al. Neuron, 2022 Jul 20. PMID 35613619, Free PMC Article
    4. straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. Ly CV, et al. J Cell Biol, 2008 Apr 7. PMID 18391075, Free PMC Article
    5. Proteogenomics of Adenosine-to-Inosine RNA Editing in the Fruit Fly. Kuznetsova KG, et al. J Proteome Res, 2018 Nov 2. PMID 30298734

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Different functions of two putative Drosophila alpha2delta subunits in the same identified motoneurons.
      Title: Different functions of two putative Drosophila α(2)δ subunits in the same identified motoneurons.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    mobile_element

    • Loc: c15654567-15653162 mobile_element_type = transposon:H{}377
    • Loc: c15688164-15686759 mobile_element_type = transposon:H{}380

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    stolid
    Names
    CG4587-PH
    CG4587-PI
    CG4587-PJ
    CG4587-PK
    CG4587-PL
    CG4587-PM
    CG4587-PN
    CG4587-PO
    stol-PH
    stol-PI
    stol-PJ
    stol-PK
    stol-PL
    stol-PM
    stol-PN
    stol-PO

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15644183..15718272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299034.1 → NP_001285963.1  stolid, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285963.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ06, A8DZ07
      Conserved Domains (4) summary
      cd01463
      Location:245 → 428
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam02743
      Location:456 → 544
      Cache_1; Cache domain
      pfam08399
      Location:108 → 230
      VWA_N; VWA N-terminal
      pfam08473
      Location:590 → 647
      VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

    2. NM_001273537.2 → NP_001260466.2  stolid, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260466.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ06, A8DZ07
      Conserved Domains (4) summary
      cd01463
      Location:245 → 428
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam02743
      Location:456 → 544
      Cache_1; Cache domain
      pfam08399
      Location:108 → 230
      VWA_N; VWA N-terminal
      pfam08473
      Location:590 → 647
      VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

    3. NM_001299033.1 → NP_001285962.1  stolid, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285962.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J9Z3
      Conserved Domains (4) summary
      cd01463
      Location:245 → 428
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam02743
      Location:456 → 544
      Cache_1; Cache domain
      pfam08399
      Location:108 → 230
      VWA_N; VWA N-terminal
      pfam08473
      Location:590 → 647
      VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

    4. NM_001103693.3 → NP_001097163.3  stolid, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097163.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ06, A8DZ07
      Conserved Domains (4) summary
      cd01463
      Location:245 → 428
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam02743
      Location:456 → 544
      Cache_1; Cache domain
      pfam08399
      Location:108 → 230
      VWA_N; VWA N-terminal
      pfam08473
      Location:590 → 647
      VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

    5. NM_001103694.3 → NP_001097164.2  stolid, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097164.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ06, A8DZ07
      Conserved Domains (4) summary
      cd01463
      Location:245 → 428
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam02743
      Location:456 → 544
      Cache_1; Cache domain
      pfam08399
      Location:108 → 230
      VWA_N; VWA N-terminal
      pfam08473
      Location:590 → 647
      VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

    6. NM_001201888.3 → NP_001188817.2  stolid, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188817.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J9Z3
      Conserved Domains (4) summary
      cd01463
      Location:245 → 428
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam02743
      Location:456 → 544
      Cache_1; Cache domain
      pfam08399
      Location:108 → 230
      VWA_N; VWA N-terminal
      pfam08473
      Location:590 → 647
      VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

    7. NM_001273538.2 → NP_001260467.2  stolid, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260467.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ06, A8DZ07
      Conserved Domains (4) summary
      cd01463
      Location:245 → 428
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam02743
      Location:456 → 544
      Cache_1; Cache domain
      pfam08399
      Location:108 → 230
      VWA_N; VWA N-terminal
      pfam08473
      Location:590 → 647
      VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

    8. NM_001299035.1 → NP_001285964.1  stolid, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285964.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ06, A8DZ07
      Conserved Domains (4) summary
      cd01463
      Location:245 → 428
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam02743
      Location:456 → 544
      Cache_1; Cache domain
      pfam08399
      Location:108 → 230
      VWA_N; VWA N-terminal
      pfam08473
      Location:590 → 647
      VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DZ06 A8DZ06
    X2J9Z3 X2J9Z3

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