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    Tsen2 tRNA splicing endonuclease subunit 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318956, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsen2provided by FlyBase
    Official Full Name
    tRNA splicing endonuclease subunit 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0051812
    Locus tag
    Dmel_CG31812
    See related
    AllianceGenome:FB:FBgn0051812
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31812; Dmel\CG31812; TSEN2
    Summary
    Predicted to enable tRNA-intron endonuclease activity. Involved in tRNA processing. Predicted to be part of tRNA-intron endonuclease complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2B. Orthologous to human TSEN2 (tRNA splicing endonuclease subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsen2 in Genome Data Viewer
    Location:
    36A12-36A12; 2-52 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16729777..16731199)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16729777..16731199)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+]-ATPase SFD subunit Neighboring gene mir-1006 stem loop Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Proteasome beta4 subunit Neighboring gene NUBP iron-sulfur cluster assembly factor 1 Neighboring gene gluon Neighboring gene Chitin and LDLR binding deacetylase 3 Neighboring gene Like Sm 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in Drosophila tRNA processing factors cause phenotypes similar to Pontocerebellar Hypoplasia. Schmidt CA, et al. Biol Open, 2022 Mar 15. PMID 35132432, Free PMC Article
    2. RNA kinase CLP1/Cbc regulates meiosis initiation in spermatogenesis. Wu J, et al. Hum Mol Genet, 2021 Aug 12. PMID 33864361, Free PMC Article
    3. Molecular determinants of metazoan tricRNA biogenesis. Schmidt CA, et al. Nucleic Acids Res, 2019 Jul 9. PMID 31032518, Free PMC Article
    4. spenito is required for sex determination in Drosophila melanogaster. Yan D, et al. Proc Natl Acad Sci U S A, 2015 Sep 15. PMID 26324914, Free PMC Article
    5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-intron endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-intron endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA splicing, via endonucleolytic cleavage and ligation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA-type intron splice site recognition and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA-intron endonuclease complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA splicing endonuclease subunit 2
    Names
    CG31812-PB
    Tsen2-PB
    NP_723994.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16729777..16731199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165179.4 → NP_723994.2  tRNA splicing endonuclease subunit 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723994.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5X0J9, Q8IP11
      Conserved Domains (2) summary
      pfam01974
      Location:119 → 203
      tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
      pfam02778
      Location:32 → 105
      tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IP11 Q8IP11

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