mirr mirror [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mirrprovided by FlyBase
Official Full Name: mirrorprovided by FlyBase
Primary source: FLYBASE:FBgn0014343
Locus tag: Dmel_CG10601
See related: AllianceGenome:FB:FBgn0014343
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10601; cre; crep; De1; De3; DH1; Dmel\CG10601; group F; Group F; iro; Iro; iro-C; Iro-C; IRO-C; IroC; l(3)69Ca; l(3)69Da; l(3)6D1; l(3)A5-3-42; mir; Mirr; MIRR; mrr; Mrr; Sai
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and protein homodimerization activity. Involved in several processes, including dorsal appendage formation; equator specification; and nervous system development. Predicted to be active in nucleus. Is expressed in several structures, including cuboidal/columnar epithelium; follicle cell; glial cell; imaginal disc; and neuroblasts. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to several human genes including IRX6 (iroquois homeobox 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 69D3-69D4; 3-38 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (12693639..12710249)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (12686739..12703349)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The relationship between Sal, Dve, and Iro-C in wing vein specification is quite similar to that in ommatidial cell-type specification. Our results provide information about the conserved function of dve regulatory motifs in cell differentiation.
Title: Spalt-mediated dve repression is a critical regulatory motif and coordinates with Iroquois complex in Drosophila vein formation.
Iro-C as a new set of transcription factors that are required for normal development of the heart
Title: The Iroquois complex is required in the dorsal mesoderm to ensure normal heart development in Drosophila.
indicate that tramtrack69 regulates ovary epithelial tube morphogenesis through Paxillin, Dynamin, and the homeobox protein Mirror.
Title: Following the 'tracks': Tramtrack69 regulates epithelial tube expansion in the Drosophila ovary through Paxillin, Dynamin, and the homeobox protein Mirror.
findings show that Mirror (Mirr), a homeodomain transcription factor induced by EGFR signaling in DA follicle cells, directly represses pipe expression by binding to a conserved element in the pipe regulatory region
Title: Mirror represses pipe expression in follicle cells to initiate dorsoventral axis formation in Drosophila.
Manipulation of mirror activity in class IV neurons retargets axonal projections and causes concordant changes in larval nociceptive escape behavior.
Title: Convergent local identity and topographic projection of sensory neurons.
Caupolican and mirror, but not araucan, are required for the neural patterning of the lateral notum and are required for stripe expression and, therefore, to specify the muscular attachment sites prepattern.
Title: Prepatterning the Drosophila notum: the three genes of the iroquois complex play intrinsically distinct roles.
Cells that overexpress a member of the Iro-C and that confront non-expressing cells establish contacts between themselves and become organized in a network of thin strings
Title: Apposition of iroquois expressing and non-expressing cells leads to cell sorting and fold formation in the Drosophila imaginal wing disc.
Capicua regulates the pattern of follicle cell fates along the dorsoventral axis by blocking the induction of appendage determinants, such as mirror, by anterior positional cues
Title: Capicua regulates follicle cell fate in the Drosophila ovary through repression of mirror.
Iroquois transcription factor Mirror recognizes a unique motif to mediate transcriptional repression in vivo.
Title: Iroquois transcription factors recognize a unique motif to mediate transcriptional repression in vivo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell development	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic development via the syncytial blastoderm	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryonic development via the syncytial blastoderm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in equator specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed