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    ldd lipid droplet defective [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318066, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lddprovided by FlyBase
    Official Full Name
    lipid droplet defectiveprovided by FlyBase
    Primary source
    FLYBASE:FBgn0083956
    Locus tag
    Dmel_CG34120
    See related
    AllianceGenome:FB:FBgn0083956
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT04622; CG1819; CG32516; CG34120; DmCG1819; Dmel\CG34120
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in adult head. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1; autosomal recessive congenital ichthyosis 4A; and autosomal recessive congenital ichthyosis 4B. Orthologous to human ABCA12 (ATP binding cassette subfamily A member 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ldd in Genome Data Viewer
    Location:
    19F1-19F1; 1-65 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21123634..21140951)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20994661..21011978)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene stargazin-like protein Neighboring gene antisense RNA:CR44374 Neighboring gene uncoordinated Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes. Moulton MJ, et al. Proc Natl Acad Sci U S A, 2021 Dec 28. PMID 34949639, Free PMC Article
    2. Systematic analysis of the visual projection neurons of Drosophila melanogaster. I. Lobula-specific pathways. Otsuna H, et al. J Comp Neurol, 2006 Aug 20. PMID 16802334
    3. ATP-Binding Cassette (ABC) Transporter Genes Involved in Pyrethroid Resistance in the Malaria Vector Anopheles sinensis: Genome-Wide Identification, Characteristics, Phylogenetics, and Expression Profile. He Q, et al. Int J Mol Sci, 2019 Mar 20. PMID 30897799, Free PMC Article
    4. TransportDB: a comprehensive database resource for cytoplasmic membrane transport systems and outer membrane channels. Ren Q, et al. Nucleic Acids Res, 2007 Jan. PMID 17135193, Free PMC Article
    5. The ABC gene family in arthropods: comparative genomics and role in insecticide transport and resistance. Dermauw W, et al. Insect Biochem Mol Biol, 2014 Feb. PMID 24291285

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 21125511-21125869 mobile_element_type = transposon:INE-1{}6026
    • Loc: 21130319-21130694 mobile_element_type = transposon:INE-1{}6028
    • Loc: 21132964-21133122 mobile_element_type = transposon:INE-1{}6029

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lipid droplet defective
    Names
    CG34120-PB
    CG34120-PC
    CG34120-PD
    CG34120-PE
    ldd-PB
    ldd-PC
    ldd-PD
    ldd-PE
    NP_001036286.1
    NP_001036287.1
    NP_001138224.1
    NP_001285513.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21123634..21140951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298584.1 → NP_001285513.1  lipid droplet defective, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285513.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BHW4, X2JG15
      Conserved Domains (4) summary
      TIGR01188
      Location:1666 → 1945
      drrA; daunorubicin resistance ABC transporter ATP-binding subunit
      cd03263
      Location:1651 → 1857
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      pfam12698
      Location:1230 → 1601
      ABC2_membrane_3; ABC-2 family transporter protein
      cl22894
      Location:1436 → 1552
      Mem_trans; Membrane transport protein

    2. NM_001042822.4 → NP_001036287.1  lipid droplet defective, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036287.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHQ2, Q5BHW4
      Conserved Domains (5) summary
      TIGR01188
      Location:1665 → 1944
      drrA; daunorubicin resistance ABC transporter ATP-binding subunit
      cd03263
      Location:1650 → 1856
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      pfam12698
      Location:1229 → 1600
      ABC2_membrane_3; ABC-2 family transporter protein
      cl14023
      Location:1371 → 1472
      DUF4400; Domain of unknown function (DUF4400)
      cl22894
      Location:1435 → 1551
      Mem_trans; Membrane transport protein

    3. NM_001144752.2 → NP_001138224.1  lipid droplet defective, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138224.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QD66, Q5BHW4
      Conserved Domains (5) summary
      TIGR01188
      Location:1649 → 1928
      drrA; daunorubicin resistance ABC transporter ATP-binding subunit
      cd03263
      Location:1634 → 1840
      ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
      pfam12698
      Location:1213 → 1584
      ABC2_membrane_3; ABC-2 family transporter protein
      cl14023
      Location:1355 → 1456
      DUF4400; Domain of unknown function (DUF4400)
      cl22894
      Location:1419 → 1535
      Mem_trans; Membrane transport protein

    4. NM_001042821.2 → NP_001036286.1  lipid droplet defective, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036286.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQ38, Q8MZF6
      Conserved Domains (1) summary
      TIGR01257
      Location:8 → 85
      rim_protein; retinal-specific rim ABC transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2QD66 E2QD66
    Q0KHQ2 Q0KHQ2
    Q5BHW4 Q5BHW4
    Q8IQ38 Q8IQ38
    Q8MZF6 Q8MZF6
    X2JG15 X2JG15

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