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    CG8726 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8726provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033244
    Locus tag
    Dmel_CG8726
    See related
    AllianceGenome:FB:FBgn0033244
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8726
    Summary
    Predicted to enable ATP binding activity; actin binding activity; and phosphatidylinositol binding activity. Predicted to be involved in modulation of chemical synaptic transmission. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including adult head; central brain primordium; embryonic antennal sense organ; ganglia; and germline cell. Used to study polycythemia due to hypoxia. Orthologous to human PXK (PX domain containing serine/threonine kinase like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8726 in Genome Data Viewer
    Location:
    43F9-43F9; 2-57 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7968129..7972003, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3855634..3859508, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Septin 5 Neighboring gene spenito Neighboring gene uncharacterized protein Neighboring gene COP9 signalosome subunit 4 Neighboring gene Acetyl-CoA carboxylase Neighboring gene Nucleoporin at 44A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New Insights into the Genetic Basis of Monge's Disease and Adaptation to High-Altitude. Stobdan T, et al. Mol Biol Evol, 2017 Dec 1. PMID 29029226, Free PMC Article
    2. Classification of nonenzymatic homologues of protein kinases. Anamika K, et al. Comp Funct Genomics, 2009. PMID 19809514, Free PMC Article
    3. RNAi screening of Drosophila (Sophophora) melanogaster S2 cells for ricin sensitivity and resistance. Pawar V, et al. J Biomol Screen, 2011 Apr. PMID 21364088, Free PMC Article
    4. Evolution of protein kinase signaling from yeast to man. Manning G, et al. Trends Biochem Sci, 2002 Oct. PMID 12368087
    5. A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Yin Z, et al. Nat Cell Biol, 2013 Jul. PMID 23748611, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein kinase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8726-PA
    CG8726-PB
    CG8726-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7968129..7972003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136497.5 → NP_610341.2  uncharacterized protein Dmel_CG8726, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610341.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z782
      Related
      FBpp0087950
      Conserved Domains (2) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:237 → 432
      PKc; Catalytic domain of Protein Kinases

    2. NM_165580.4 → NP_724634.1  uncharacterized protein Dmel_CG8726, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724634.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z783
      Related
      FBpp0087949
      Conserved Domains (2) summary
      cd00180
      Location:154 → 349
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    3. NM_001169608.2 → NP_001163079.1  uncharacterized protein Dmel_CG8726, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163079.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQL4, Q95RK3
      Conserved Domains (2) summary
      cd00180
      Location:154 → 349
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z782 A1Z782
    A1Z783 A1Z783
    Q8MQL4 Q8MQL4
    Q95RK3 Q95RK3

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