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    Pfdn1 Prefoldin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33857, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pfdn1provided by FlyBase
    Official Full Name
    Prefoldin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031776
    Locus tag
    Dmel_CG13993
    See related
    AllianceGenome:FB:FBgn0031776
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey288; CG13993; Dmel\CG13993; pfdn1
    Summary
    Predicted to enable protein folding chaperone and unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; larval muscle system; and larval nervous system. Orthologous to human PFDN1 (prefoldin subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pfdn1 in Genome Data Viewer
    Location:
    26B4-26B4; 2-18 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6069079..6069838)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6069079..6069838)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Kruppel homolog 2 Neighboring gene long non-coding RNA:CR43801

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic variation in a member of the laminin gene family affects variation in body composition in Drosophila and humans. De Luca M, et al. BMC Genet, 2008 Aug 11. PMID 18694491, Free PMC Article
    2. Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation. Zhang Y, et al. Sci Rep, 2016 Mar 30. PMID 27025979, Free PMC Article
    3. Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex [corrected]. Palumbo V, et al. Curr Biol, 2015 Jun 29. PMID 26096973, Free PMC Article
    4. Promoter-Proximal Chromatin Domain Insulator Protein BEAF Mediates Local and Long-Range Communication with a Transcription Factor and Directly Activates a Housekeeping Promoter in Drosophila. Dong Y, et al. Genetics, 2020 May. PMID 32179582, Free PMC Article
    5. A targeted gain-of-function screen identifies genes affecting salivary gland morphogenesis/tubulogenesis in Drosophila. Maybeck V, et al. Genetics, 2009 Feb. PMID 19064711, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of prefoldin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prefoldin 1
    Names
    CG13993-PA
    CG13993-PB
    Pfdn1-PA
    Pfdn1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6069079..6069838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135148.3 → NP_608992.1  prefoldin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608992.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMH8
      Related
      FBpp0078822
      Conserved Domains (1) summary
      pfam01920
      Location:13 → 116
      Prefoldin_2; Prefoldin subunit

    2. NM_001298732.1 → NP_001285661.1  prefoldin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285661.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMH8
      Conserved Domains (1) summary
      pfam01920
      Location:13 → 116
      Prefoldin_2; Prefoldin subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMH8 Q9VMH8

    Gene LinkOut

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