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    CG42237 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32261, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42237provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0250862
    Locus tag
    Dmel_CG42237
    See related
    AllianceGenome:FB:FBgn0250862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    C133; CG4346; Dmel\CG42237; PLA2
    Old locus tag
    Dmel_CG4346
    Summary
    Predicted to enable calcium-dependent phospholipase A2 activity. Predicted to be involved in arachidonate secretion and phospholipid metabolic process. Is expressed in adult head and organism. Orthologous to human PROCA1 (protein interacting with cyclin A1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42237 in Genome Data Viewer
    Location:
    11E1-11E1; 1-42 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13115131..13123066)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13009164..13017099)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Chondroitin polymerizing factor Neighboring gene Ferritin 3 heavy chain homologue Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA 204 Neighboring gene uncharacterized protein Neighboring gene Major Facilitator Superfamily Transporter 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila spermatid individualization is sensitive to temperature and fatty acid metabolism. Ben-David G, et al. Spermatogenesis, 2015 Jan-Apr. PMID 26413411, Free PMC Article
    2. The Drosophila radish gene encodes a protein required for anesthesia-resistant memory. Folkers E, et al. Proc Natl Acad Sci U S A, 2006 Nov 14. PMID 17088531, Free PMC Article
    3. Deconstructing memory in Drosophila. Margulies C, et al. Curr Biol, 2005 Sep 6. PMID 16139203, Free PMC Article
    4. Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila. Renault AD, et al. Mech Dev, 2002 Dec. PMID 14516700
    5. Neutral Competition for Drosophila Follicle and Cyst Stem Cell Niches Requires Vesicle Trafficking Genes. Cook MS, et al. Genetics, 2017 Jul. PMID 28512187, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42237-PA
    CG42237-PB
    phospholipase A2
    NP_001285185.1
    NP_572855.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13115131..13123066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298256.1 → NP_001285185.1  uncharacterized protein Dmel_CG42237, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285185.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JBI9
      Conserved Domains (1) summary
      cd04704
      Location:200 → 294
      PLA2_bee_venom_like; PLA2_bee_venom_like: A sub-family of Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the ...

    2. NM_132627.2 → NP_572855.1  uncharacterized protein Dmel_CG42237, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572855.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYG9
      Related
      FBpp0073553
      Conserved Domains (1) summary
      cd04704
      Location:254 → 348
      PLA2_bee_venom_like; PLA2_bee_venom_like: A sub-family of Phospholipase A2, similar to bee venom PLA2. PLA2 is a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYG9 Q9VYG9
    X2JBI9 X2JBI9

    Gene LinkOut

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