PH4alphaSG2 prolyl-4-hydroxylase-alpha SG2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PH4alphaSG2provided by FlyBase
Official Full Name: prolyl-4-hydroxylase-alpha SG2provided by FlyBase
Primary source: FLYBASE:FBgn0039779
Locus tag: Dmel_CG1546
See related: AllianceGenome:FB:FBgn0039779
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1546; Dmel\CG1546; SG2
Summary: Predicted to enable procollagen-proline 4-dioxygenase activity. Involved in salivary gland morphogenesis. Located in endoplasmic reticulum. Is expressed in embryonic/larval salivary gland; embryonic/larval salivary gland body; and salivary gland body primordium. Orthologous to human P4HA3 (prolyl 4-hydroxylase subunit alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (30490074..30491987)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (26315796..26317709)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression of PH4alphaSG2 was directly regulated by Fkh and Sage.
Title: Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2.

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Function	Evidence Code	Pubs
enables L-ascorbic acid binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables procollagen-proline 4-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables procollagen-proline 4-dioxygenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

NP_651801.1

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The following sections contain reference sequences that belong to a specific genome build. Explain