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    toc toucan [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33526, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tocprovided by FlyBase
    Official Full Name
    toucanprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015600
    Locus tag
    Dmel_CG9660
    See related
    AllianceGenome:FB:FBgn0015600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BA34; BcDNA:LD27161; CG9660; Dmel\CG9660; EN2-11; l(2)01361; l(2)05527; l(2)k08224; l(2)K08224; Toc
    Summary
    Predicted to enable microtubule binding activity. Involved in syncytial blastoderm mitotic cell cycle. Located in several cellular components, including microtubule cytoskeleton; midbody; and nuclear membrane. Is expressed in several structures, including amnioserosa anlage; anlage in statu nascendi; ganglia; gonad; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See toc in Genome Data Viewer
    Location:
    23D1-23D2; 2-8 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3068345..3144786, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3068345..3144786, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene small nuclear RNA U5 at 23D Neighboring gene Fatty acid synthase 2 Neighboring gene Fatty acid synthase 1 Neighboring gene Protein phosphatase D6 Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B14.5 B subunit Neighboring gene Mothers against dpp

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila Toucan protein is a new mitotic microtubule-associated protein required for spindle microtubule stability. Mirouse V, et al. Genes Cells, 2005 Jan. PMID 15670212
    2. Expression and cellular localization of the Toucan protein during Drosophila oogenesis. Grammont M, et al. Mech Dev, 2000 Feb. PMID 10640714
    3. minifly, a Drosophila gene required for ribosome biogenesis. Giordano E, et al. J Cell Biol, 1999 Mar 22. PMID 10087258, Free PMC Article
    4. Requirement of RBP9, a Drosophila Hu homolog, for regulation of cystocyte differentiation and oocyte determination during oogenesis. Kim-Ha J, et al. Mol Cell Biol, 1999 Apr. PMID 10082516, Free PMC Article
    5. Natural Genetic Variation and Candidate Genes for Morphological Traits in Drosophila melanogaster. Carreira VP, et al. PLoS One, 2016. PMID 27459710, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that Toucan is a microtubule-associated protein specifically required for the stability of spindle microtubules throughout mitosis.
      Title: The Drosophila Toucan protein is a new mitotic microtubule-associated protein required for spindle microtubule stability.
    2. Essential for the assembly of syncytial mitotic spindles in D. melanogaster embryo.
      Title: Toucan protein is essential for the assembly of syncytial mitotic spindles in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in syncytial blastoderm mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    toucan
    Names
    CG9660-PA
    CG9660-PB
    CG9660-PC
    CG9660-PD
    CG9660-PE
    CG9660-PF
    CG9660-PG
    CG9660-PH
    CG9660-PI
    CG9660-PJ
    enhancer of NA9 2-11
    toc-PA
    toc-PB
    toc-PC
    toc-PD
    toc-PE
    toc-PF
    toc-PG
    toc-PH
    toc-PI
    toc-PJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3068345..3144786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057805.3 → NP_477153.1  toucan, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477153.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46112, Q9VQM0
      Related
      FBpp0077346
      Conserved Domains (5) summary
      COG1340
      Location:1580 → 1850
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      pfam04094
      Location:1302 → 1737
      DUF390; Protein of unknown function (DUF390)
      pfam11068
      Location:1642 → 1712
      YlqD; YlqD protein
      pfam16043
      Location:1652 → 1826
      DUF4795; Domain of unknown function (DUF4795)
      cl23720
      Location:1550 → 1668
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. NM_001273061.1 → NP_001259990.1  toucan, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259990.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PED5
      Conserved Domains (2) summary
      pfam09731
      Location:63 → 406
      Mitofilin; Mitochondrial inner membrane protein
      pfam12325
      Location:469 → 568
      TMF_TATA_bd; TATA element modulatory factor 1 TATA binding

    3. NM_001042864.2 → NP_001036329.1  toucan, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036329.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8U3, Q8MRI5
      Conserved Domains (2) summary
      pfam12325
      Location:522 → 621
      TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
      cl23720
      Location:333 → 451
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    4. NM_001273059.1 → NP_001259988.1  toucan, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259988.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCH2, Q8MRI5
      Conserved Domains (1) summary
      pfam12325
      Location:522 → 621
      TMF_TATA_bd; TATA element modulatory factor 1 TATA binding

    5. NM_164526.2 → NP_722877.1  toucan, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722877.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQL8
      Related
      FBpp0077349
      Conserved Domains (1) summary
      pfam12325
      Location:570 → 669
      TMF_TATA_bd; TATA element modulatory factor 1 TATA binding

    6. NM_001273058.1 → NP_001259987.1  toucan, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259987.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBW7
      Conserved Domains (1) summary
      pfam12325
      Location:417 → 516
      TMF_TATA_bd; TATA element modulatory factor 1 TATA binding

    7. NM_001103594.2 → NP_001097064.1  toucan, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097064.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYU0, H1UUP1
      Conserved Domains (1) summary
      COG1196
      Location:71 → 397
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    8. NM_001273060.1 → NP_001259989.1  toucan, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259989.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PC13, Q8MRI5
      Conserved Domains (3) summary
      pfam09731
      Location:111 → 450
      Mitofilin; Mitochondrial inner membrane protein
      pfam12325
      Location:513 → 612
      TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
      cl23720
      Location:324 → 442
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    9. NM_164524.2 → NP_722875.2  toucan, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722875.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPZ2, Q8MRI5
      Related
      FBpp0077347
      Conserved Domains (2) summary
      pfam10473
      Location:500 → 643
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      cl23720
      Location:372 → 490
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    10. NM_164525.2 → NP_722876.1  toucan, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722876.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPZ1
      Related
      FBpp0077348
      Conserved Domains (2) summary
      pfam09731
      Location:63 → 402
      Mitofilin; Mitochondrial inner membrane protein
      pfam12325
      Location:465 → 564
      TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYU0 A8DYU0
    M9PBW7 M9PBW7
    M9PC13 M9PC13
    M9PCH2 M9PCH2
    M9PED5 M9PED5
    O46112 O46112
    Q0E8U3 Q0E8U3
    Q8IPZ1 Q8IPZ1
    Q8IPZ2 Q8IPZ2
    Q8MRI5 Q8MRI5
    Q9VQL8 Q9VQL8
    Q9VQM0 Q9VQM0

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