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    ko knockout [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40330, updated on 9-Dec-2024

    Summary

    Official Symbol
    koprovided by FlyBase
    Official Full Name
    knockoutprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020294
    Locus tag
    Dmel_CG10573
    See related
    AllianceGenome:FB:FBgn0020294
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10573; Dmel\CG10573
    Summary
    Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in motor neuron axon guidance. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including amnioproctodeal invagination; embryonic head epidermis; embryonic/larval dorsal vessel; gut section; and larval somatic muscle cell. Human ortholog(s) of this gene implicated in pre-eclampsia. Orthologous to human STOX1 (storkhead box 1) and STOX2 (storkhead box 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    Location:
    78B1-78B2; 3-47 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21075581..21131159, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21068681..21124259, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene RNA polymerase III subunit E Neighboring gene schizo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45945 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Islet cell autoantigen 69 kDa Neighboring gene Adenylyl cyclase 78C

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    knockout
    Names
    CG10573-PA
    CG10573-PB
    ko-PA
    ko-PB

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21075581..21131159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079469.3NP_524193.2  knockout, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524193.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWN7, Q9VP79
      Related
      FBpp0077980
      Conserved Domains (1) summary
      pfam10264
      Location:119195
      Stork_head; Winged helix Storkhead-box1 domain
    2. NM_001275206.1NP_001262135.1  knockout, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262135.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6AWN7, Q9VP79
      Conserved Domains (1) summary
      pfam10264
      Location:119195
      Stork_head; Winged helix Storkhead-box1 domain