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    CG7668 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40190, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7668provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036929
    Locus tag
    Dmel_CG7668
    See related
    AllianceGenome:FB:FBgn0036929
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF49079; AAM11109; AAN11645; BcDNA:GM07843; BcDNA:RE40293; Dmel\CG7668; FBpp0074673; FBpp0074674
    Summary
    Predicted to be active in collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in cardiovascular system disease (multiple); congenital afibrinogenemia; and end stage renal disease. Orthologous to human FGB (fibrinogen beta chain) and TNN (tenascin N). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7668 in Genome Data Viewer
    Location:
    76E1-76E1; 3-46 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20002736..20004834)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19995836..19997934)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Neurocalcin Neighboring gene gamma-aminobutyric acid transaminase Neighboring gene Translocase of outer membrane 20 Neighboring gene kugelei Neighboring gene uncharacterized protein Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of the fibrinogen-like domain of fibrinogen-related proteins in the mosquito, Anopheles gambiae, and the fruitfly, Drosophila melanogaster, genomes. Wang X, et al. BMC Genomics, 2005 Sep 8. PMID 16150145, Free PMC Article
    2. Evolution and potential function of fibrinogen-like domains across twelve Drosophila species. Middha S, et al. BMC Genomics, 2008 May 30. PMID 18513432, Free PMC Article
    3. Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Zdobnov EM, et al. Science, 2002 Oct 4. PMID 12364792
    4. Genome-wide phenotypic RNAi screen in the Drosophila wing: global parameters. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599819, Free PMC Article
    5. Insect response to alphavirus infection--establishment of alphavirus persistence in insect cells involves inhibition of viral polyprotein cleavage. Mudiganti U, et al. Virus Res, 2010 Jun. PMID 20214937

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7668-PA
    CG7668-PC
    Fibrinogen-related protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20002736..20004834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168830.2 → NP_730478.2  uncharacterized protein Dmel_CG7668, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730478.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQU9, Q8SYR0, Q9VW70
      Conserved Domains (2) summary
      pfam01519
      Location:146 → 212
      DUF16; Protein of unknown function DUF16
      cl00085
      Location:245 → 421
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    2. NM_140913.2 → NP_649170.1  uncharacterized protein Dmel_CG7668, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649170.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQU9, Q8SYR0, Q9VW70
      Related
      FBpp0074673
      Conserved Domains (2) summary
      pfam01519
      Location:146 → 212
      DUF16; Protein of unknown function DUF16
      cl00085
      Location:245 → 421
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYR0 Q8SYR0
    Q8T3M7 Q8T3M7
    Q9VW70 Q9VW70

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