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    SEC31 Sec31p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851332, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SEC31
    Official Full Name
    Sec31p
    Primary source
    SGD:S000002354
    Locus tag
    YDL195W
    See related
    AllianceGenome:SGD:S000002354; FungiDB:YDL195W; VEuPathDB:YDL195W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    WEB1
    Summary
    Enables structural molecule activity. Involved in COPII-coated vesicle budding. Located in mating projection tip. Part of COPII vesicle coat. Human ortholog(s) of this gene implicated in Halperin-Birk syndrome. Orthologous to several human genes including SEC31A (SEC31 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SEC31 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (107208..111029)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Ggc1p Neighboring gene Asf2p Neighboring gene glucose sensor Neighboring gene ditrans,polycis-polyprenyl diphosphate synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast. Bednarek SY, et al. Cell, 1995 Dec 29. PMID 8548805
    2. Suppression of mutations in two Saccharomyces cerevisiae genes by the adenovirus E1A protein. Zieler HA, et al. Mol Cell Biol, 1995 Jun. PMID 7760818, Free PMC Article
    3. Involvement of the penta-EF-hand protein Pef1p in the Ca2+-dependent regulation of COPII subunit assembly in Saccharomyces cerevisiae. Yoshibori M, et al. PLoS One, 2012. PMID 22792405, Free PMC Article
    4. Structure and organization of coat proteins in the COPII cage. Fath S, et al. Cell, 2007 Jun 29. PMID 17604721
    5. New mutants of Saccharomyces cerevisiae affected in the transport of proteins from the endoplasmic reticulum to the Golgi complex. Wuestehube LJ, et al. Genetics, 1996 Feb. PMID 8852839, Free PMC Article

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural molecule activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle budding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in COPII-coated vesicle budding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPII vesicle coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ER to Golgi transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mating projection tip HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sec31p
    NP_010086.2
    • Component of the Sec13p-Sec31p complex of the COPII vesicle coat; COPII coat is required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      107208..111029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180255.2 → NP_010086.2  TPA: Sec31p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010086.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRF8, P38968
      UniProtKB/TrEMBL
      B3LH77, B5VF81, C8Z6A8, G2WBX1
      Conserved Domains (4) summary
      PHA03247
      Location:772 → 1172
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:12 → 61
      7WD40; WD40 repeat [structural motif]
      pfam11549
      Location:899 → 946
      Sec31; Protein transport protein SEC31
      cl29593
      Location:17 → 327
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38968.3

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