TRK2 Trk2p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TRK2
Official Full Name: Trk2p
Primary source: SGD:S000001758
Locus tag: YKR050W
See related: AllianceGenome:SGD:S000001758; FungiDB:YKR050W; VEuPathDB:YKR050W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RPD2
Summary: Enables potassium ion transmembrane transporter activity. Involved in intracellular calcium ion homeostasis; intracellular potassium ion homeostasis; and regulation of membrane potential. Located in cell periphery. Is active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TRK2 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (527815..530484)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Minority potassium-uptake system Trk2 has a crucial role in yeast survival of glucose-induced cell death.
Title: Minority potassium-uptake system Trk2 has a crucial role in yeast survival of glucose-induced cell death.
Using a combination of physiological, biochemical and proteomic approaches, we show that during growth at suboptimal potassium concentrations, double trk1,2 mutants accumulate less potassium and reach lower yields.
Title: A physiological, biochemical and proteomic characterization of Saccharomyces cerevisiae trk1,2 transport mutants grown under limiting potassium conditions.
Trk2 is the major potassium uptake system in stationary cells, and potassium content to be a crucial parameter for desiccation survival.
Title: Potassium uptake system Trk2 is crucial for yeast cell viability during anhydrobiosis.
TRK2 overexpression improved the ability of trk1 cells to grow in low K(+) and led to a higher accumulation of K(+).
Title: Trk2 transporter is a relevant player in K+ supply and plasma-membrane potential control in Saccharomyces cerevisiae.
Results indicate that, in addition to their role in regulating Trk1 and 2 potassium transporters, Ppz phosphatases 1 and 2 positively affect the residual low affinity potassium transport mechanisms in yeast.
Title: The Ppz protein phosphatases regulate Trk-independent potassium influx in yeast.
TRK2 encodes a functional potassium ion transporter that, under specific experimental conditions, displays distinctive kinetic characteristics.
Title: The yeast potassium transporter TRK2 is able to substitute for TRK1 in its biological function under low K and low pH conditions.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables high-affinity potassium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular potassium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular potassium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Trk2p

NP_012976.1

Component of the Trk1p-Trk2p potassium transport system; contributes to K(+) supply and maintenance of plasma-membrane potential; TRK2 has a paralog, TRK1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

527815..530484

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179840.1 → NP_012976.1 TPA: Trk2p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012976.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXB1, P28584

UniProtKB/TrEMBL

G2WI78, N1NZH8

Conserved Domains (1) summary

TIGR00934
Location:4 → 839

2a38euk; potassium uptake protein, Trk family