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    GFD1 Gfd1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855297, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GFD1
    Official Full Name
    Gfd1p
    Primary source
    SGD:S000004868
    Locus tag
    YMR255W
    See related
    AllianceGenome:SGD:S000004868; FungiDB:YMR255W; VEuPathDB:YMR255W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mRNA export from nucleus. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GFD1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (778001..778567)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene cytochrome c oxidase subunit VII Neighboring gene Pet111p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Study of a region on yeast chromosome XIII that complements pet G199 mutants (COX7) and carries a new non-essential gene. Nobrega MP, et al. Braz J Med Biol Res, 1998 Mar. PMID 9698782
    2. Structure of the N-terminal Mlp1-binding domain of the Saccharomyces cerevisiae mRNA-binding protein, Nab2. Grant RP, et al. J Mol Biol, 2008 Feb 29. PMID 18190927, Free PMC Article
    3. Structural basis for the function of the Saccharomyces cerevisiae Gfd1 protein in mRNA nuclear export. Zheng C, et al. J Biol Chem, 2010 Jul 2. PMID 20463024, Free PMC Article
    4. Nuclear export of the yeast mRNA-binding protein Nab2 is linked to a direct interaction with Gfd1 and to Gle1 function. Suntharalingam M, et al. J Biol Chem, 2004 Aug 20. PMID 15208322
    5. The Dbp5 cycle at the nuclear pore complex during mRNA export I: dbp5 mutants with defects in RNA binding and ATP hydrolysis define key steps for Nup159 and Gle1. Hodge CA, et al. Genes Dev, 2011 May 15. PMID 21576265, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gfd1 serves as a bridging factor between Gle1 and Nab2-bound mRNA during export
      Title: Nuclear export of the yeast mRNA-binding protein Nab2 is linked to a direct interaction with Gfd1 and to Gle1 function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Gfd1p
    NP_013982.1
    • Coiled-coiled hypothetical protein; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      778001..778567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182762.1 → NP_013982.1  TPA: Gfd1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013982.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W081, Q04839
      UniProtKB/TrEMBL
      A6ZMX0, B3LME3, B5VQ21, C7GR97, C8ZFC1, N1P5X7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04839.1

    Gene LinkOut

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