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    NRP1 Nrp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851387, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NRP1
    Official Full Name
    Nrp1p
    Primary source
    SGD:S000002326
    Locus tag
    YDL167C
    See related
    AllianceGenome:SGD:S000002326; FungiDB:YDL167C; VEuPathDB:YDL167C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable mRNA binding activity. Located in cytoplasmic stress granule. Orthologous to several human genes including TEX13C (TEX13 family member C); TEX13D (TEX13 family member D); and TEX13A (testis expressed 13A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NRP1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (160995..163154, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Ugx2p Neighboring gene bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase Neighboring gene nucleoside-triphosphatase Neighboring gene CCR4-NOT core subunit CDC36

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption and functional analysis of six ORFs of chromosome IV: YDL103c (QRI1), YDL105w (QRI2), YDL112w (TRM3), YDL113c, YDL116w (NUP84) and YDL167c (NRP1). Reynaud A, et al. Yeast, 2001 Feb. PMID 11180460
    2. Cellular factors required for protection from hyperoxia toxicity in Saccharomyces cerevisiae. Outten CE, et al. Biochem J, 2005 May 15. PMID 15641941, Free PMC Article
    3. Evolutionary adaptation after crippling cell polarization follows reproducible trajectories. Laan L, et al. Elife, 2015 Oct 1. PMID 26426479, Free PMC Article
    4. Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules. Kroschwald S, et al. Elife, 2015 Aug 4. PMID 26238190, Free PMC Article
    5. Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates. Malinovska L, et al. Mol Biol Cell, 2012 Aug. PMID 22718905, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasmic stress granule HDA PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nrp1p
    NP_010114.1
    • Putative RNA binding hypothetical protein; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      160995..163154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180227.1 → NP_010114.1  TPA: Nrp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010114.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRI4, P32770, Q12228
      UniProtKB/TrEMBL
      B5VFA5, C7GL15, C8Z6D6
      Conserved Domains (3) summary
      sd00029
      Location:585 → 604
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:581 → 609
      zf-RanBP; Zn-finger in Ran binding protein and others
      cd12452
      Location:226 → 328
      RRM_ARP_like; RNA recognition motif (RRM) found in yeast asparagine-rich protein (ARP) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32770.2

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