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    MIC27 Mic27p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855623, updated on 27-Dec-2024

    Summary

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    Official Symbol
    MIC27
    Official Full Name
    Mic27p
    Primary source
    SGD:S000005044
    Locus tag
    YNL100W
    See related
    AllianceGenome:SGD:S000005044; FungiDB:YNL100W; VEuPathDB:YNL100W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AIM37; MCS27
    Summary
    Involved in cristae formation and protein-containing complex organization. Acts upstream of or within positive regulation of protein oligomerization. Located in mitochondrial crista junction. Part of MICOS complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MIC27 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (437613..438317)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene DNA-directed DNA polymerase alpha catalytic subunit POL1 Neighboring gene Avt4p Neighboring gene putative tyrosine protein phosphatase OCA1 Neighboring gene Ras family GTPase RAS2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assembly of the Mitochondrial Cristae Organizer Mic10 Is Regulated by Mic26-Mic27 Antagonism and Cardiolipin. Rampelt H, et al. J Mol Biol, 2018 Jun 22. PMID 29733859
    2. Mic60 exhibits a coordinated clustered distribution along and across yeast and mammalian mitochondria. Stoldt S, et al. Proc Natl Acad Sci U S A, 2019 May 14. PMID 31028145, Free PMC Article
    3. Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System. Zerbes RM, et al. J Mol Biol, 2016 Apr 24. PMID 26968360
    4. Myristoyl group-aided protein import into the mitochondrial intermembrane space. Ueda E, et al. Sci Rep, 2019 Feb 4. PMID 30718713, Free PMC Article
    5. Aim24 and MICOS modulate respiratory function, tafazzin-related cardiolipin modification and mitochondrial architecture. Harner ME, et al. Elife, 2014 Jan 1. PMID 24714493, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results find that Mic26 and Mic27 regulate Mic10 oligomerization in an antagonistic manner.
      Title: Assembly of the Mitochondrial Cristae Organizer Mic10 Is Regulated by Mic26-Mic27 Antagonism and Cardiolipin.
    2. in addition to the MICOS core components Mic10 and Mic60, Mic12 and Mic27 play specific roles in the organization of the MICOS complex
      Title: Distinct Roles of Mic12 and Mic27 in the Mitochondrial Contact Site and Cristae Organizing System.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cristae formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein oligomerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-containing complex organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MICOS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial crista junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mic27p
    NP_014299.1
    • Component of the MICOS complex; MICOS (formerly MINOS or MitOS), a mitochondrial inner membrane complex that extends into the intermembrane space with a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic10p and Mic12p whose assembly and stability requires cardiolipin; positive regulator of Mic10p oligomerization along with cardiolipin; orthologous to human APOO and APOOL

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      437613..438317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182938.1 → NP_014299.1  TPA: Mic27p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014299.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZRY0, B3LNV9, B5VQU2, C7GR78, D6W179, P50945, Q45U03
      UniProtKB/TrEMBL
      G2WM04, N1NXX3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50945.1

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