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    PHO13 4-nitrophenylphosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851362, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PHO13
    Official Full Name
    4-nitrophenylphosphatase
    Primary source
    SGD:S000002395
    Locus tag
    YDL236W
    See related
    AllianceGenome:SGD:S000002395; FungiDB:YDL236W; VEuPathDB:YDL236W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alkaline phosphatase activity; phosphoglycolate phosphatase activity; and phosphoprotein phosphatase activity. Involved in carbohydrate metabolic process. Located in cytoplasm and nucleus. Orthologous to human PGP (phosphoglycolate phosphatase) and PDXP (pyridoxal phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PHO13 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (32296..33234)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene guanine deaminase Neighboring gene Aim6p Neighboring gene Ypd1p Neighboring gene GTPase-activating protein GYP7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a specific p-nitrophenylphosphatase gene, PHO13, and its mapping by chromosome fragmentation in Saccharomyces cerevisiae. Kaneko Y, et al. Mol Gen Genet, 1989 Dec. PMID 2558283
    2. A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast. Collard F, et al. Nat Chem Biol, 2016 Aug. PMID 27294321
    3. Deleting the para-nitrophenyl phosphatase (pNPPase), PHO13, in recombinant Saccharomyces cerevisiae improves growth and ethanol production on D-xylose. Van Vleet JH, et al. Metab Eng, 2008 Nov. PMID 18249574
    4. Deletion of the PHO13 gene in Saccharomyces cerevisiae improves ethanol production from lignocellulosic hydrolysate in the presence of acetic and formic acids, and furfural. Fujitomi K, et al. Bioresour Technol, 2012 May. PMID 22357292
    5. A specific alkaline phosphatase from Saccharomyces cerevisiae with protein phosphatase activity. Tuleva B, et al. FEMS Microbiol Lett, 1998 Apr 1. PMID 9561742

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphoglycolate phosphatase rescues central carbon metabolism from toxic secondary metabolites in humans and yeast.
      Title: A Guardian Angel Phosphatase for Mainline Carbon Metabolism.
    2. a conserved phosphatase (in yeast and mammals) destroys toxic glycolytic side products
      Title: A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast.
    3. Transcriptome sequencing analysis revealed that pho13Delta resulted in upregulation of the pentose phosphate (PP) pathway and NADPH-producing enzymes when cells were grown on glucose or xylose.
      Title: Deletion of PHO13, encoding haloacid dehalogenase type IIA phosphatase, results in upregulation of the pentose phosphate pathway in Saccharomyces cerevisiae.
    4. findings demonstrate that PHO13 deletion is a simple, but effective, approach for improving cellulosic bioethanol production by S. cerevisiae
      Title: Deletion of the PHO13 gene in Saccharomyces cerevisiae improves ethanol production from lignocellulosic hydrolysate in the presence of acetic and formic acids, and furfural.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alkaline phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkaline phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoglycolate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoglycolate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    4-nitrophenylphosphatase
    NP_010045.1
    • Conserved phosphatase acting as a metabolite repair enzyme; shows specific dephosphorylating activity on two side-products of central carbohydrate metabolism, 2-phosphoglycolate and 4-phosphoerythronate; alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity; human ortholog PGP shows similar substrate specificity, deletion causes similar metabolite accumulation phenotypes, suggesting conserved role in eliminating glycolytic byproducts

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      32296..33234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180296.1 → NP_010045.1  TPA: 4-nitrophenylphosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010045.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRC0, P19881, Q07689
      UniProtKB/TrEMBL
      A6ZX98, B3LHB2, B5VF45, C7GJQ5, N1PA86
      Conserved Domains (1) summary
      cd07510
      Location:24 → 308
      HAD_Pase_UmpH-like; UmpH/NagD family phosphatase, similar to human PGP phosphoglycolate phosphatase and Schizosaccharomyces pombe PHO2 p-nitrophenylphosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19881.2

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