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    Prickle4 prickle planar cell polarity protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 381104, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prickle4provided by MGI
    Official Full Name
    prickle planar cell polarity protein 4provided by MGI
    Primary source
    MGI:MGI:2685785
    See related
    Ensembl:ENSMUSG00000096549 AllianceGenome:MGI:2685785
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm939
    Summary
    Predicted to enable actin binding activity and muscle alpha-actinin binding activity. Predicted to be involved in actin cytoskeleton organization; heart development; and muscle structure development. Predicted to be part of filamentous actin. Predicted to be active in Z disc; adherens junction; and stress fiber. Orthologous to human PRICKLE4 (prickle planar cell polarity protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in stomach adult (RPKM 9.2), CNS E18 (RPKM 4.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prickle4 in Genome Data Viewer
    Location:
    17 C; 17 23.87 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47999399..48005834, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47688474..47694910, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 20517 Neighboring gene mediator complex subunit 20 Neighboring gene Kpna2 retrotransposed pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10959 Neighboring gene ubiquitin specific peptidase 49 Neighboring gene translocase of outer mitochondrial membrane 6, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E4218 Neighboring gene translocase of outer mitochondrial membrane 6 Neighboring gene fibroblast growth factor receptor substrate 3 Neighboring gene STARR-seq mESC enhancer starr_42721 Neighboring gene fibroblast growth factor receptor substrate 3, opposite strand Neighboring gene predicted gene, 46579

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis. Ru J, et al. Invest Ophthalmol Vis Sci, 2020 Nov 2. PMID 33141892, Free PMC Article
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables muscle alpha-actinin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle structure development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of filamentous actin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prickle-like protein 4
    Names
    prickle homolog 4
    translocase of outer mitochondrial membrane 6 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290337.1 → NP_001277266.1  prickle-like protein 4

      See identical proteins and their annotated locations for NP_001277266.1

      Status: VALIDATED

      Source sequence(s)
      AC139214, BQ042537, BX525727
      Consensus CDS
      CCDS70823.1
      UniProtKB/TrEMBL
      D3Z6Q6, F6ZPB0
      Related
      ENSMUSP00000108925.2, ENSMUST00000113300.8
      Conserved Domains (3) summary
      cd09340
      Location:124 → 181
      LIM1_Testin_like; The first LIM domain of Testin-like family
      cd09341
      Location:187 → 241
      LIM2_Testin_like; The second LIM domain of Testin-like family
      cd09828
      Location:1 → 116
      PET_OEBT; The PET domain of overexpressed breast tumor protein (OEBT)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      47999399..48005834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160670.1 → XP_036016563.1  prickle-like protein 4 isoform X1

      Conserved Domains (2) summary
      cd09340
      Location:124 → 181
      LIM1_Testin_like; The first LIM domain of Testin-like family
      cd09828
      Location:1 → 116
      PET_OEBT; The PET domain of overexpressed breast tumor protein (OEBT)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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