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    Ctbs chitobiase [ Mus musculus (house mouse) ]

    Gene ID: 74245, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ctbsprovided by MGI
    Official Full Name
    chitobiaseprovided by MGI
    Primary source
    MGI:MGI:1921495
    See related
    Ensembl:ENSMUSG00000028189 AllianceGenome:MGI:1921495
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CTB; 2210401K11Rik
    Summary
    Predicted to enable chitinase activity. Predicted to be involved in chitin catabolic process and oligosaccharide catabolic process. Predicted to be located in lysosome. Is expressed in ventricular layer. Orthologous to human CTBS (chitobiase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 4.4), kidney adult (RPKM 3.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ctbs in Genome Data Viewer
    Location:
    3 H2; 3 71.26 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (146156204..146171604)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146450449..146465849)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22078 Neighboring gene SSX family member 2 interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E9230 Neighboring gene spermatogenesis associated 1 Neighboring gene STARR-positive B cell enhancer ABC_E6144 Neighboring gene G protein subunit gamma 5 Neighboring gene STARR-positive B cell enhancer ABC_E11229 Neighboring gene ribosome production factor 1 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lysosomal di-N-acetylchitobiase-deficient mouse tissues accumulate Man2GlcNAc2 and Man3GlcNAc2. Persichetti E, et al. Biochim Biophys Acta, 2012 Jul. PMID 22465033
    2. Molecular cloning and structural organization of the gene encoding the mouse lysosomal di-N-acetylchitobiase (ctbs). Balducci C, et al. Gene, 2008 Jun 15. PMID 18440730
    3. New paralogues and revised time line in the expansion of the vertebrate GH18 family. Hussain M, et al. J Mol Evol, 2013 Apr. PMID 23558346
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In di-N-acetylchitobiase-deficient mice Man2GlcNAc2 urine levels were up to 10-fold higher than in urine of wild-type animals.
      Title: Lysosomal di-N-acetylchitobiase-deficient mouse tissues accumulate Man2GlcNAc2 and Man3GlcNAc2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligosaccharide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligosaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    di-N-acetylchitobiase
    Names
    chitobiase, di-N-acetyl-
    NP_001280601.1
    NP_083112.1
    XP_030108705.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293672.2 → NP_001280601.1  di-N-acetylchitobiase isoform 1 precursor

      See identical proteins and their annotated locations for NP_001280601.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC124987
      Consensus CDS
      CCDS80048.1
      UniProtKB/Swiss-Prot
      Q8R242, Q9D7V4
      UniProtKB/TrEMBL
      Q102J0
      Related
      ENSMUSP00000059167.7, ENSMUST00000061937.13
      Conserved Domains (2) summary
      cd02875
      Location:24 → 362
      GH18_chitobiase; Chitobiase (also known as di-N-acetylchitobiase) is a lysosomal glycosidase that hydrolyzes the reducing-end N-acetylglucosamine from the chitobiose core of oligosaccharides during the ordered degradation of asparagine-linked glycoproteins in eukaryotes. ...
      smart00636
      Location:99 → 342
      Glyco_18; Glyco_18 domain

    2. NM_028836.5 → NP_083112.1  di-N-acetylchitobiase isoform 2 precursor

      See identical proteins and their annotated locations for NP_083112.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC124987
      Consensus CDS
      CCDS17902.1
      UniProtKB/Swiss-Prot
      Q8R242
      Related
      ENSMUSP00000029840.4, ENSMUST00000029840.4
      Conserved Domains (2) summary
      smart00636
      Location:99 → 288
      Glyco_18; Glyco_18 domain
      cl10447
      Location:24 → 308
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...

    RNA

    1. NR_190655.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124987

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      146156204..146171604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252845.1 → XP_030108705.1  di-N-acetylchitobiase isoform X1

      Conserved Domains (1) summary
      cl10447
      Location:1 → 244
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R242.2 GenPept UniProtKB/Swiss-Prot:Q8R242

    Gene LinkOut

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