Pimreg PICALM interacting mitotic regulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pimregprovided by MGI
Official Full Name: PICALM interacting mitotic regulatorprovided by MGI
Primary source: MGI:MGI:1924434
See related: Ensembl:ENSMUSG00000020808 AllianceGenome:MGI:1924434
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CATS; Fam64a; 2610008F03Rik; 6720460F02Rik
Summary: Predicted to be involved in cell division. Predicted to be located in nucleolus and nucleoplasm. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; integumental system; and limb. Orthologous to human PIMREG (PICALM interacting mitotic regulator). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E11.5 (RPKM 26.3), limb E14.5 (RPKM 16.9) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B4; 11 43.81 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (71932867..71938197)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (72042428..72047372)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

regulates Th17 differentiation and colitis and inflammation-associated cancer by modulating transcriptional activity of STAT3
Title: FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis.
Expression of a non-degradable Fam64a mutant suggested that optimum Fam64a expression and subsequent degradation by anaphase-promoting complex/cyclosome (APC/C) during the metaphase-to-anaphase transition are required for fetal cardiomyocyte division. We propose that Fam64a is a novel cell cycle promoter of hypoxic fetal cardiomyocytes in mice.
Title: Fam64a is a novel cell cycle promoter of hypoxic fetal cardiomyocytes in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI115087 (e-PCR)
- UniSTS:180243

6720460F02Rik (e-PCR), detects polymorphism
- UniSTS:526059

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein PIMREG

Names: CALM-interactor expressed in thymus and spleen homolog; family with sequence similarity 64, member A; protein FAM64A; regulator of chromosome segregation protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418158.1 → NP_001405087.1 protein PIMREG

Status: VALIDATED

Source sequence(s)

BX119911

UniProtKB/Swiss-Prot

Q8BFY7, Q8K2Z7

UniProtKB/TrEMBL

Q8VDW8
NM_001418159.1 → NP_001405088.1 protein PIMREG

Status: VALIDATED

Source sequence(s)

BX119911

UniProtKB/Swiss-Prot

Q8BFY7, Q8K2Z7

UniProtKB/TrEMBL

Q8VDW8
NM_144526.4 → NP_653109.2 protein PIMREG

See identical proteins and their annotated locations for NP_653109.2

Status: VALIDATED

Source sequence(s)

BX119911

Consensus CDS

CCDS48840.1

UniProtKB/Swiss-Prot

Q8BFY7, Q8K2Z7

UniProtKB/TrEMBL

Q8VDW8

Related

ENSMUSP00000021164.4, ENSMUST00000021164.4

Conserved Domains (1) summary

pfam07326
Location:1 → 221

DUF1466; Protein of unknown function (DUF1466)