Nat10 N-acetyltransferase 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nat10provided by MGI
Official Full Name: N-acetyltransferase 10provided by MGI
Primary source: MGI:MGI:2138939
See related: Ensembl:ENSMUSG00000027185 AllianceGenome:MGI:2138939
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable DNA polymerase binding activity; N-acetyltransferase activity; and tRNA binding activity. Predicted to be involved in several processes, including rRNA acetylation involved in maturation of SSU-rRNA; regulation of centrosome duplication; and regulation of macromolecule biosynthetic process. Predicted to be located in midbody. Predicted to be part of small-subunit processome and telomerase holoenzyme complex. Predicted to be active in nucleolus. Is expressed in several structures, including alimentary system; clavicle; cranium bone primordium; early conceptus; and skeletal musculature. Orthologous to human NAT10 (N-acetyltransferase 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 9.4), CNS E11.5 (RPKM 8.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E2; 2 54.43 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (103551603..103593292, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (103721258..103762954, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis.
Title: NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis.
N-acetyltransferase 10 mediates cognitive dysfunction through the acetylation of GABABR1 mRNA in sepsis-associated encephalopathy.
Title: N-acetyltransferase 10 mediates cognitive dysfunction through the acetylation of GABA(B)R1 mRNA in sepsis-associated encephalopathy.
The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury.
Title: The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury.
NAT10-mediated ac[4]C-modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1.
Title: NAT10-mediated ac(4)C-modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1.
N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration.
Title: N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration.
NAT10 Is Involved in Cardiac Remodeling Through ac4C-Mediated Transcriptomic Regulation.
Title: NAT10 Is Involved in Cardiac Remodeling Through ac4C-Mediated Transcriptomic Regulation.
NAT10 regulates the repair of UVB-induced DNA damage and tumorigenicity.
Title: NAT10 regulates the repair of UVB-induced DNA damage and tumorigenicity.
NAT10-mediated ac4C tRNA modification promotes EGFR mRNA translation and gefitinib resistance in cancer.
Title: NAT10-mediated ac4C tRNA modification promotes EGFR mRNA translation and gefitinib resistance in cancer.
Targeting NAT10 protects against sepsis-induced skeletal muscle atrophy by inhibiting ROS/NLRP3.
Title: Targeting NAT10 protects against sepsis-induced skeletal muscle atrophy by inhibiting ROS/NLRP3.
NAT10 regulates the LPS-induced inflammatory response via the NOX2-ROS-NF-kappaB pathway in macrophages.
Title: NAT10 regulates the LPS-induced inflammatory response via the NOX2-ROS-NF-κB pathway in macrophages.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI429152 (e-PCR)
- UniSTS:158992

NoName (e-PCR)
- UniSTS:234476

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables mRNA N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables mRNA N-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables rRNA cytidine N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of telomere maintenance via telomerase	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein acetylation	ISO Inferred from Sequence Orthology more info
involved_in protein acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in rRNA acetylation involved in maturation of SSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA acetylation involved in maturation of SSU-rRNA	IEA Inferred from Electronic Annotation more info
involved_in regulation of centrosome duplication	ISO Inferred from Sequence Orthology more info
involved_in regulation of centrosome duplication	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA acetylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA acetylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA wobble cytosine modification	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info
part_of telomerase holoenzyme complex	IEA Inferred from Electronic Annotation more info
part_of telomerase holoenzyme complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA cytidine acetyltransferase

Names: 18S rRNA cytosine acetyltransferase; novel putative ATPase domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001424713.1 → NP_001411642.1 RNA cytidine acetyltransferase isoform 2

Status: VALIDATED

Source sequence(s)

BX537331
NM_153126.4 → NP_694766.1 RNA cytidine acetyltransferase

See identical proteins and their annotated locations for NP_694766.1

Status: VALIDATED

Source sequence(s)

BX537331

Consensus CDS

CCDS16480.1

UniProtKB/Swiss-Prot

Q3UE04, Q6ZPJ7, Q80VD3, Q8BW78, Q8K224

Related

ENSMUSP00000028608.7, ENSMUST00000028608.13

Conserved Domains (6) summary

COG1444
Location:20 → 901

TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]

pfam05127
Location:281 → 480

Helicase_RecD; Helicase

pfam08351
Location:107 → 201

DUF1726; Domain of unknown function (DUF1726)

pfam09074
Location:855 → 1005

Mer2; Mer2

pfam13718
Location:528 → 752

GNAT_acetyltr_2; GNAT acetyltransferase 2

pfam13725
Location:775 → 892

tRNA_bind_2; Possible tRNA binding domain

RNA

NR_188870.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

BX537331

Related

ENSMUST00000143017.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

103551603..103593292 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162741.1 → XP_036018634.1 RNA cytidine acetyltransferase isoform X1
XM_006500455.5 → XP_006500518.1 RNA cytidine acetyltransferase isoform X2

Conserved Domains (1) summary

COG1444
Location:20 → 851

TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]